Duke vs. Wake Forest Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers expect a close contest when the Duke Blue Devils (6-5) host the Wake Forest Demon Deacons (8-3) on Saturday, November 29, 2025 in a matchup between ACC foes at Brooks Field at Wallace Wade Stadium. Duke is favored by 2.5 points. The contest has an over/under of 53.5 points.

The Blue Devils beat the North Carolina Tar Heels, 32-25, in their most recent contest. Facing the Delaware Blue Hens in their most recent contest, the Demon Deacons won 52-14.

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Duke vs. Wake Forest Game Information & Odds

When: Saturday, November 29, 2025 at 3:30 p.m. ET
Location: Brooks Field at Wallace Wade Stadium in Wilmington, North Carolina
TV: ACC Network
Live Box Score on FOX Sports

Duke vs Wake Forest Betting Information updated as of November 29, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Duke	-2.5 (-106)	-127	+108	53.5	-113	-107

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Duke vs. Wake Forest Prediction

Pick ATS: Wake Forest (+2.5)
Pick OU: Over (53.5)
Prediction: Wake Forest 27, Duke 26

Predictions are made by the Data Skrive betting model.

Learn more about the Duke Blue Devils vs. the Wake Forest Demon Deacons game on FOX Sports!

Duke vs. Wake Forest Betting Insights

Based on the spread and over/under, the implied score for the tilt is Blue Devils 28, Demon Deacons 26.
The Blue Devils have a 55.9% chance to claim victory in this contest per the moneyline's implied probability. The Demon Deacons have a 48.1% implied probability.
Duke has won four games against the spread this season, while failing to cover or pushing seven times.
Wake Forest has put together an 8-3-0 ATS record so far this year.

Duke vs. Wake Forest: Head-to-Head

Duke has a 3-1 record against Wake Forest in their last four matchups.
The Blue Devils and the Demon Deacons have matched up evenly over their last four games, holding a split 2-2 record against the spread. In those four head-to-head matchups, the two squads have hit the over on the point total on one occasion.
Over their last four head-to-head contests, Wake Forest has scored 114 points, while Duke has posted 88.

Duke vs. Wake Forest: 2025 Stats Comparison

	Duke	Wake Forest
Off. Points per Game (Rank)	33.3 (33)	26.4 (79)
Def. Points per Game (Rank)	29.2 (95)	19 (18)
Turnovers Allowed (Rank)	11 (21)	16 (87)
Turnovers Forced (Rank)	15 (54)	15 (54)

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	3,182 YDS (67.4%) / 26 TD / 4 INT
Nate Sheppard	RB	790 YDS / 7 TD / 71.8 YPG / 5.9 YPC 25 REC / 175 REC YDS / 1 REC TD / 15.9 REC YPG
Cooper Barkate	WR	55 REC / 895 YDS / 6 TD / 81.4 YPG
Anderson Castle	RB	414 YDS / 9 TD / 37.6 YPG / 5 YPC 15 REC / 93 REC YDS / 0 REC TD / 11.6 REC YPG
Caleb Weaver	DB	72 TKL / 3 TFL / 1.5 SACK / 1 INT
Vincent Anthony Jr.	DL	29 TKL / 9 TFL / 6.5 SACK
DaShawn Stone	DB	64 TKL / 0 TFL / 1 INT / 1 PD
Luke Mergott	LB	60 TKL / 4 TFL / 1 SACK

Wake Forest 2025 Key Players

Name	Position	Stats
Robby Ashford	QB	1,827 YDS (58.5%) / 7 TD / 6 INT 460 RUSH YDS / 6 RUSH TD / 46 RUSH YPG
Demond Claiborne	RB	849 YDS / 10 TD / 77.2 YPG / 5.1 YPC 26 REC / 130 REC YDS / 0 REC TD / 13 REC YPG
Chris Barnes	WR	37 REC / 523 YDS / 3 TD / 52.3 YPG
Carlos Hernandez	WR	28 REC / 445 YDS / 3 TD / 40.5 YPG
Langston Hardy	DL	54 TKL / 9 TFL / 6 SACK
Nick Andersen	DB	84 TKL / 4 TFL
Dylan Hazen	LB	59 TKL / 4 TFL
Nuer Gatkuoth	DL	33 TKL / 6 TFL / 6 SACK / 1 INT