Duke vs. UConn Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

Data Skrive

A pair of the nation's strongest passing attacks square off when the Duke Blue Devils (5-3) bring college football's fourth-ranked passing offense into a matchup with the UConn Huskies (6-3), who have the No. 12 passing offense, on Saturday, November 8, 2025. The Blue Devils are 7.5-point favorites. The contest has a point total set at 63.5.

In their most recent action, the Blue Devils won versus the Clemson Tigers, 46-45. The Huskies won against the UAB Blazers in their most recent game, 38-19.

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Duke vs. UConn Game Information & Odds

When: Saturday, November 8, 2025 at 3:30 p.m. ET
Location: Pratt and Whitney Stadium at Rentschler Field in East Hartford, Connecticut
TV: CBS Sports Network
Live Box Score on FOX Sports

Duke vs UConn Betting Information updated as of November 8, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Duke	-7.5 (-112)	-303	+241	63.5	-113	-108

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Duke vs. UConn Prediction

Pick ATS: UConn (+7.5)
Pick OU: Under (63.5)
Prediction: Duke 34, UConn 28

Predictions are made by the Data Skrive betting model.

Learn more about the Duke Blue Devils vs. the UConn Huskies game on FOX Sports!

Duke vs. UConn Betting Insights

Based on the spread and over/under, the implied score for the game is Blue Devils 36, Huskies 28.
The Blue Devils have a 75.2% chance to claim victory in this meeting based on the moneyline's implied probability. The Huskies have a 29.3% implied probability.
Duke is 4-4-0 ATS this season.
UConn has compiled a 4-3-2 ATS record so far this year.

Duke vs. UConn: Head-to-Head

Duke owns a 2-0 record against UConn in their last two matchups.
In their most recent two matchups, each team has covered one time with those contests outscoring the point total on one occasion.
Over their last two head-to-head contests, Duke has put up 67 points, while UConn has accumulated 28.

Duke vs. UConn: 2025 Stats Comparison

	Duke	UConn
Off. Points per Game (Rank)	35.4 (35)	36.9 (11)
Def. Points per Game (Rank)	28.1 (82)	23.9 (69)
Turnovers Allowed (Rank)	7 (14)	1 (1)
Turnovers Forced (Rank)	13 (35)	11 (56)

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	2,572 YDS (69.7%) / 21 TD / 2 INT
Cooper Barkate	WR	45 REC / 774 YDS / 5 TD / 96.8 YPG
Nate Sheppard	RB	557 YDS / 5 TD / 69.6 YPG / 6.6 YPC 20 REC / 143 REC YDS / 1 REC TD / 17.9 REC YPG
Anderson Castle	RB	319 YDS / 6 TD / 39.9 YPG / 5.5 YPC 12 REC / 81 REC YDS / 0 REC TD / 13.5 REC YPG
Vincent Anthony Jr.	DL	25 TKL / 8 TFL / 6.5 SACK
Caleb Weaver	DB	56 TKL / 2 TFL / 0.5 SACK / 1 INT
DaShawn Stone	DB	50 TKL / 0 TFL / 1 INT / 1 PD
Jaiden Francois	LB	43 TKL / 0 TFL / 1 SACK

UConn 2025 Key Players

Name	Position	Stats
Joe Fagnano	QB	2,529 YDS (68.8%) / 22 TD / 0 INT 91 RUSH YDS / 2 RUSH TD / 10.1 RUSH YPG
Skyler Bell	WR	74 REC / 994 YDS / 11 TD / 110.4 YPG
Cam Edwards	RB	815 YDS / 9 TD / 90.6 YPG / 5.7 YPC 9 REC / 90 REC YDS / 1 REC TD / 15 REC YPG
Javonte Vereen	TE	17 REC / 259 YDS / 4 TD / 32.4 YPG
Bryun Parham	LB	72 TKL / 9 TFL / 9.5 SACK
Oumar Diomande	LB	69 TKL / 5 TFL / 4 SACK
Cam Chadwick	DB	46 TKL / 1 TFL / 1 SACK / 4 INT
Malachi McLean	DB	51 TKL / 2 TFL / 1 SACK