Duke vs. Cal Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 9:04 p.m. ET

FOX Sports

The California Golden Bears (4-1) are 3-point underdogs in a home conference matchup with the Duke Blue Devils (3-2) on Saturday, October 4, 2025 at California Memorial Stadium. The game has a point total of 54.5.

Last time out, the Blue Devils defeated the Syracuse Orange, with 38-3 being the final score. The Golden Bears beat the Boston College Eagles, 28-24, in their last contest.

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Duke vs. Cal Game Information & Odds

When: Saturday, October 4, 2025 at 10:30 p.m. ET
Location: California Memorial Stadium in Berkeley, California
TV: ESPN
Live Box Score on FOX Sports

Duke vs Cal Betting Information updated as of October 4, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Duke	-3 (-112)	-162	+136	54.5	-114	-106

Duke vs. Cal Prediction

Pick ATS: Cal (+3)
Pick OU: Under (54.5)
Prediction: Duke 28, Cal 25

Predictions are made by the Data Skrive betting model.

Learn more about the Duke Blue Devils vs. the California Golden Bears game on FOX Sports!

Duke vs. Cal Betting Insights

Per the spread and over/under, the implied score for the tilt is Blue Devils 29, Golden Bears 26.
The Blue Devils have a 61.8% chance to win this meeting based on the moneyline's implied probability. The Golden Bears hold a 42.4% implied probability.
Duke has won two games against the spread this season.
Cal has covered three times in five games with a spread this year.

Duke vs. Cal: 2025 Stats Comparison

	Duke	Cal
Off. Points per Game (Rank)	34.8 (36)	24.8 (91)
Def. Points per Game (Rank)	26.4 (86)	18 (36)
Turnovers Allowed (Rank)	7 (85)	6 (66)
Turnovers Forced (Rank)	8 (32)	7 (43)

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	1,573 YDS (69.1%) / 13 TD / 2 INT
Nate Sheppard	RB	356 YDS / 2 TD / 71.2 YPG / 8.1 YPC 13 REC / 96 REC YDS / 1 REC TD / 19.2 REC YPG
Cooper Barkate	WR	21 REC / 409 YDS / 3 TD / 81.8 YPG
Anderson Castle	RB	235 YDS / 4 TD / 47 YPG / 7.3 YPC 11 REC / 80 REC YDS / 0 REC TD / 16 REC YPG
Vincent Anthony Jr.	DL	15 TKL / 6 TFL / 5 SACK
Caleb Weaver	DB	38 TKL / 0 TFL / 0.5 SACK / 1 INT
DaShawn Stone	DB	35 TKL / 0 TFL / 1 INT / 1 PD
Jaiden Francois	LB	32 TKL / 0 TFL / 1 SACK

Cal 2025 Key Players

Name	Position	Stats
Jaron-Keawe Sagapolutele	QB	1,234 YDS (61.6%) / 8 TD / 4 INT 21 RUSH YDS / 1 RUSH TD / 4.2 RUSH YPG
Kendrick Raphael	RB	356 YDS / 2 TD / 71.2 YPG / 4.7 YPC
Trond Grizzell	WR	20 REC / 344 YDS / 1 TD / 68.8 YPG
Mason Mini	TE	23 REC / 223 YDS / 3 TD / 44.6 YPG
Cade Uluave	LB	26 TKL / 5 TFL / 1 SACK
Hezekiah Masses	DB	14 TKL / 0 TFL / 4 INT / 4 PD
Ryan McCulloch	LB	10 TKL / 2 TFL / 1.5 SACK
Luke Ferrelli	LB	15 TKL / 1 TFL / 1 INT / 1 PD