Clemson vs. SMU Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

FOX Sports

The Clemson Tigers (3-3) are 3.5-point favorites when they host the SMU Mustangs (4-2) in conference play on Saturday, October 18, 2025 at Memorial Stadium (Clemson, SC). The over/under is 50.5 for this matchup.

Against the Boston College Eagles in their most recent contest, the Tigers won 41-10. In their most recent game, the Mustangs won versus the Stanford Cardinal, 34-10.

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Clemson vs. SMU Game Information & Odds

When: Saturday, October 18, 2025 at 3:30 p.m. ET
Location: Memorial Stadium (Clemson, SC) in Clemson, South Carolina
TV: ACC Network
Live Box Score on FOX Sports

Clemson vs SMU Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Clemson	-3.5 (-109)	-175	+147	50.5	-108	-117

Clemson vs. SMU Prediction

Pick ATS: SMU (+3.5)
Pick OU: Over (50.5)
Prediction: Clemson 27, SMU 24

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the SMU Mustangs game on FOX Sports!

Clemson vs. SMU Betting Insights

Per the spread and over/under, the implied score for the matchup is Tigers 27, Mustangs 24.
The Tigers have a 63.6% chance to win this meeting per the moneyline's implied probability. The Mustangs have a 40.5% implied probability.
Clemson has covered twice in six matchups with a spread this season.
SMU has covered just once in five matchups with a spread this year.

Clemson vs. SMU: 2025 Stats Comparison

	Clemson	SMU
Off. Points per Game (Rank)	26.3 (88)	34 (49)
Def. Points per Game (Rank)	18.5 (25)	22.3 (53)
Turnovers Allowed (Rank)	11 (116)	9 (93)
Turnovers Forced (Rank)	7 (72)	14 (2)

Clemson 2025 Key Players

Name	Position	Stats
Cade Klubnik	QB	1,530 YDS (65.8%) / 11 TD / 5 INT 104 RUSH YDS / 2 RUSH TD / 17.3 RUSH YPG
Adam Randall	RB	404 YDS / 4 TD / 67.3 YPG / 5.4 YPC 19 REC / 163 REC YDS / 3 REC TD / 32.6 REC YPG
Bryant Wesco Jr.	WR	31 REC / 537 YDS / 6 TD / 89.5 YPG
T.J. Moore	WR	21 REC / 283 YDS / 1 TD / 47.2 YPG
Sammy Brown	LB	39 TKL / 3 TFL / 2 SACK
Ronan Hanafin	DB	38 TKL / 0 TFL / 1 INT / 1 PD
Avieon Terrell	DB	25 TKL / 1 TFL / 1 SACK
Wade Woodaz	LB	38 TKL / 2 TFL

SMU 2025 Key Players

Name	Position	Stats
Kevin Jennings	QB	1,658 YDS (71.7%) / 15 TD / 6 INT 6 RUSH YDS / 1 RUSH TD / 1 RUSH YPG
Tomarion Harden	RB	414 YDS / 5 TD / 69 YPG / 4.9 YPC 5 REC / 24 REC YDS / 0 REC TD / 12 REC YPG
Romello Brinson	WR	32 REC / 484 YDS / 3 TD / 80.7 YPG
Chris Johnson Jr.	RB	226 YDS / 2 TD / 45.2 YPG / 8.1 YPC 8 REC / 122 REC YDS / 1 REC TD / 24.4 REC YPG
Cam Robertson	DL	24 TKL / 5 TFL / 4.5 SACK
Ahmaad Moses	DB	37 TKL / 3 TFL / 1 SACK / 2 INT
Isaiah Nwokobia	DB	36 TKL / 0 TFL / 1 INT / 1 PD
Jeffrey M'ba	DL	14 TKL / 4 TFL / 4 SACK