Clemson vs. Duke Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 9:04 a.m. ET

Data Skrive

The Clemson Tigers (3-4), who have college football's 21st-ranked passing offense, meet the Duke Blue Devils (4-3) and their fourth-ranked passing attack on Saturday, November 1, 2025. The Tigers are 3.5-point favorites. The total is 54.5 points for this game.

Last time out, the Tigers fell to the SMU Mustangs, with 35-24 being the final score. In their most recent game, the Blue Devils lost versus the Georgia Tech Yellow Jackets, 27-18.

Keep up with college football all season on FOX Sports.

Clemson vs. Duke Game Information & Odds

When: Saturday, November 1, 2025 at 12 p.m. ET
Location: Memorial Stadium (Clemson, SC) in Clemson, South Carolina
TV: ACC Network
Live Box Score on FOX Sports

Clemson vs Duke Betting Information updated as of November 1, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Clemson	-3.5 (-108)	-169	+142	54.5	-110	-110

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Clemson vs. Duke Prediction

Pick ATS: Duke (+3.5)
Pick OU: Under (54.5)
Prediction: Duke 28, Clemson 25

Predictions are made by the Data Skrive betting model.

Learn more about the Clemson Tigers vs. the Duke Blue Devils game on FOX Sports!

Clemson vs. Duke Betting Insights

Per the spread and over/under, the implied score for the tilt is Tigers 29, Blue Devils 26.
The Tigers have a 62.8% chance to collect the win in this meeting based on the moneyline's implied probability. The Blue Devils hold a 41.3% implied probability.
Clemson has a record of 2-5-0 against the spread this season.
Duke has put together a 3-4-0 record against the spread this season.

Clemson vs. Duke: 2025 Stats Comparison

	Clemson	Duke
Off. Points per Game (Rank)	26 (99)	33.9 (55)
Def. Points per Game (Rank)	20.9 (26)	25.7 (58)
Turnovers Allowed (Rank)	12 (100)	7 (23)
Turnovers Forced (Rank)	8 (85)	12 (32)

Clemson 2025 Key Players

Name	Position	Stats
Cade Klubnik	QB	1,530 YDS (65.8%) / 11 TD / 5 INT 104 RUSH YDS / 2 RUSH TD / 17.3 RUSH YPG
Adam Randall	RB	433 YDS / 4 TD / 61.9 YPG / 5.1 YPC 24 REC / 182 REC YDS / 3 REC TD / 30.3 REC YPG
Bryant Wesco Jr.	WR	31 REC / 537 YDS / 6 TD / 76.7 YPG
T.J. Moore	WR	26 REC / 407 YDS / 3 TD / 58.1 YPG
Sammy Brown	LB	48 TKL / 4 TFL / 2 SACK
Ronan Hanafin	DB	41 TKL / 0 TFL / 1 INT / 1 PD
Wade Woodaz	LB	43 TKL / 2 TFL / 0.5 SACK
Will Heldt	DL	25 TKL / 6 TFL / 3 SACK

Duke 2025 Key Players

Name	Position	Stats
Darian Mensah	QB	2,211 YDS (70.3%) / 17 TD / 2 INT
Nate Sheppard	RB	497 YDS / 4 TD / 71 YPG / 7 YPC 18 REC / 132 REC YDS / 1 REC TD / 18.9 REC YPG
Cooper Barkate	WR	39 REC / 647 YDS / 4 TD / 92.4 YPG
Anderson Castle	RB	295 YDS / 6 TD / 42.1 YPG / 5.6 YPC 12 REC / 81 REC YDS / 0 REC TD / 13.5 REC YPG
Vincent Anthony Jr.	DL	22 TKL / 8 TFL / 6.5 SACK
Caleb Weaver	DB	51 TKL / 2 TFL / 0.5 SACK / 1 INT
DaShawn Stone	DB	44 TKL / 0 TFL / 1 INT / 1 PD
Wesley Williams	DL	23 TKL / 3 TFL / 2 SACK