Cincinnati vs. Iowa State Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 9:04 a.m. ET

Data Skrive

The Cincinnati Bearcats (3-1) take the 16th-ranked scoring offense in college football into a matchup with the No. 14 Iowa State Cyclones (5-0), who have the No. 18 scoring defense, on Saturday, October 4, 2025. The Bearcats are just 1-point favorites. This matchup has an over/under of 55.5 points.

The Bearcats' most recent game was versus the Kansas Jayhawks, and they won by a score of 37-34. The Cyclones won against the Arizona Wildcats in their last game, 39-14.

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Cincinnati vs. Iowa State Game Information & Odds

When: Saturday, October 4, 2025 at 12 p.m. ET
Location: Nippert Stadium in Cincinnati, Ohio
TV: ESPN2
Live Box Score on FOX Sports

Cincinnati vs Iowa State Betting Information updated as of October 4, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Cincinnati	-1 (-110)	-115	-104	55.5	-111	-109

Cincinnati vs. Iowa State Prediction

Pick ATS: Iowa State (+1)
Pick OU: Under (55.5)
Prediction: Cincinnati 24, Iowa State 23

Predictions are made by the Data Skrive betting model.

Learn more about the Cincinnati Bearcats vs. the Iowa State Cyclones game on FOX Sports!

Cincinnati vs. Iowa State Betting Insights

Based on the spread and over/under, the implied score for the matchup is Bearcats 28, Cyclones 27.
The Bearcats have a 53.5% chance to collect the win in this meeting per the moneyline's implied probability. The Cyclones have a 51.0% implied probability.
Cincinnati has put together a 3-1-0 ATS record so far this year.
Iowa State has put together a 3-1-1 ATS record so far this year.

Cincinnati vs. Iowa State: Head-to-Head

Over their last two meetings, Iowa State has tallied two wins against Cincinnati.
In those matchups versus Cincinnati, the Cyclones have covered two times while never hitting the over on the point total.
Over their last two head-to-head contests, Iowa State has put up 64 points, while Cincinnati has tallied 27.

Cincinnati vs. Iowa State: 2025 Stats Comparison

	Cincinnati	Iowa State
Off. Points per Game (Rank)	39.5 (32)	31.6 (32)
Def. Points per Game (Rank)	18.5 (30)	14.2 (26)
Turnovers Allowed (Rank)	3 (18)	5 (53)
Turnovers Forced (Rank)	2 (126)	8 (24)

Cincinnati 2025 Key Players

Name	Position	Stats
Brendan Sorsby	QB	1,043 YDS (69.2%) / 10 TD / 1 INT 227 RUSH YDS / 4 RUSH TD / 56.8 RUSH YPG
Cyrus Allen	WR	23 REC / 273 YDS / 5 TD / 68.3 YPG
Tawee Walker	RB	224 YDS / 3 TD / 56 YPG / 5.3 YPC 5 REC / 21 REC YDS / 1 REC TD / 5.3 REC YPG
Caleb Goodie	WR	13 REC / 251 YDS / 1 TD / 62.8 YPG
Jake Golday	LB	33 TKL / 2 TFL / 2 SACK
Antawn Peek Jr.	LB	13 TKL / 1 TFL / 1 SACK
Jonathan Thompson	LB	18 TKL / 1 TFL / 1 SACK
Brian Simms III	LB	10 TKL / 2 TFL / 2 SACK

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	1,103 YDS (65.8%) / 7 TD / 2 INT 38 RUSH YDS / 5 RUSH TD / 7.6 RUSH YPG
Carson Hansen	RB	315 YDS / 2 TD / 63 YPG / 4.3 YPC 10 REC / 77 REC YDS / 0 REC TD / 15.4 REC YPG
Benjamin Brahmer	TE	16 REC / 138 YDS / 3 TD / 27.6 YPG
Abu Sama III	RB	208 YDS / 2 TD / 41.6 YPG / 4.2 YPC
Marcus Neal	DB	30 TKL / 5 TFL / 1 SACK
Jamison Patton	DB	25 TKL / 0 TFL / 2 INT / 2 PD
Kooper Ebel	LB	18 TKL / 1 TFL / 1 SACK
Tamatoa McDonough	DL	9 TKL / 2 TFL / 2 SACK