Central Michigan vs. Eastern Michigan Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 9:04 a.m. ET

Data Skrive

The Central Michigan Chippewas (2-2) are 3.5-point favorites when they host the Eastern Michigan Eagles (1-3) in conference play on Saturday, September 27, 2025 at Kelly/Shorts Stadium. The total for this game has been set at 55 points.

Against the Wagner Seahawks in their last game, the Chippewas won 49-10. Last time around, the Eagles defeated the Louisiana Ragin' Cajuns, with 34-31 being the final score.

Keep up with college football all season on FOX Sports.

Central Michigan vs. Eastern Michigan Game Information & Odds

When: Saturday, September 27, 2025 at 1 p.m. ET
Location: Kelly/Shorts Stadium in Mount Pleasant, Michigan
TV: ESPN+
Live Box Score on FOX Sports

Central Michigan vs Eastern Michigan Betting Information updated as of September 27, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Central Michigan	-3.5 (-104)	-157	+133	55	-110	-110

Central Michigan vs. Eastern Michigan Prediction

Pick ATS: Eastern Michigan (+3.5)
Pick OU: Over (55)
Prediction: Eastern Michigan 34, Central Michigan 28

Predictions are made by the Data Skrive betting model.

Learn more about the Central Michigan Chippewas vs. the Eastern Michigan Eagles game on FOX Sports!

Central Michigan vs. Eastern Michigan Betting Insights

Per the spread and over/under, the implied score for the matchup is Chippewas 29, Eagles 26.
The Chippewas have a 61.1% chance to collect the win in this meeting based on the moneyline's implied probability. The Eagles hold a 42.9% implied probability.
Central Michigan has won two games against the spread this season.
Eastern Michigan has won two games against the spread this season.

Central Michigan vs. Eastern Michigan: Head-to-Head

The last four times Eastern Michigan and Central Michigan have matched up, the two teams share a split 2-2 record.
In those contests against Central Michigan, the Eagles have covered three times while outpacing the point total on three occasions.
In their last four head-to-head matchups, Central Michigan has compiled 110 points against Eastern Michigan, while giving up only 109 points.

Central Michigan vs. Eastern Michigan: 2025 Stats Comparison

	Central Michigan	Eastern Michigan
Off. Points per Game (Rank)	21.3 (104)	26.8 (77)
Def. Points per Game (Rank)	33 (126)	39.8 (131)
Turnovers Allowed (Rank)	5 (74)	2 (17)
Turnovers Forced (Rank)	7 (14)	2 (116)

Central Michigan 2025 Key Players

Name	Position	Stats
Angel Flores	QB	115 YDS (68.4%) / 1 TD / 0 INT 155 RUSH YDS / 2 RUSH TD / 38.8 RUSH YPG
Nahree Biggins	RB	129 YDS / 0 TD / 32.3 YPG / 3.9 YPC 8 REC / 123 REC YDS / 1 REC TD / 30.8 REC YPG
Joey Labas	QB	422 YDS (69.6%) / 4 TD / 1 INT
Trey Cornist	RB	180 YDS / 1 TD / 45 YPG / 4.3 YPC
Michael Heldman	DL	10 TKL / 1 TFL / 3 SACK
Dakota Cochran	LB	14 TKL / 0 TFL / 1 INT / 1 PD
Jordan Kwiatkowski	LB	16 TKL / 0 TFL / 1 INT / 1 PD
Elijah Rikard	DB	13 TKL / 0 TFL / 1 INT / 1 PD

Eastern Michigan 2025 Key Players

Name	Position	Stats
Noah Kim	QB	993 YDS (64%) / 5 TD / 2 INT 55 RUSH YDS / 2 RUSH TD / 13.8 RUSH YPG
Dontae McMillan	RB	345 YDS / 1 TD / 86.3 YPG / 7 YPC 9 REC / 101 REC YDS / 1 REC TD / 25.3 REC YPG
Tavierre Dunlap	RB	119 YDS / 3 TD / 29.8 YPG / 3.2 YPC 5 REC / 59 REC YDS / 0 REC TD / 19.7 REC YPG
Terry Lockett Jr.	WR	18 REC / 259 YDS / 1 TD / 64.8 YPG
Bryce Llewellyn	DB	25 TKL / 2 TFL / 1 INT / 1 PD
Barry Manning	DB	18 TKL / 1 TFL
Carter Evans	DL	13 TKL / 2 TFL
Marco Patierno	LB	19 TKL / 0 TFL