BYU vs. Colorado Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 9:04 p.m. ET

FOX Sports

The BYU Cougars (3-0) are favored by 6.5 points when they hit the road to play the Colorado Buffaloes (2-2) in Big 12 action on Saturday, September 27, 2025 at Folsom Field. The point total is set at 49.5 for the contest.

In their most recent game, the Cougars won versus the East Carolina Pirates, 34-13. The Buffaloes' last game was against the Wyoming Cowboys, and they won by a score of 37-20.

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BYU vs. Colorado Game Information & Odds

When: Saturday, September 27, 2025 at 10:15 p.m. ET
Location: Folsom Field in Boulder, Colorado
TV: ESPN
Live Box Score on FOX Sports

BYU vs Colorado Betting Information updated as of September 27, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
BYU	-6.5 (-113)	-246	+201	49.5	-110	-110

BYU vs. Colorado Prediction

Pick ATS: BYU (-6.5)
Pick OU: Under (49.5)
Prediction: BYU 38, Colorado 6

Predictions are made by the Data Skrive betting model.

Learn more about the BYU Cougars vs. the Colorado Buffaloes game on FOX Sports!

BYU vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the tilt is Cougars 28, Buffaloes 22.
The Cougars have a 71.1% chance to win this game based on the moneyline's implied probability. The Buffaloes have a 33.2% implied probability.
BYU has covered in each of its three games with a spread this season.
Colorado has won two games against the spread this season.

BYU vs. Colorado: 2025 Stats Comparison

	BYU	Colorado
Off. Points per Game (Rank)	43.3 (53)	27 (84)
Def. Points per Game (Rank)	5.3 (1)	22.5 (60)
Turnovers Allowed (Rank)	1 (4)	3 (25)
Turnovers Forced (Rank)	6 (35)	5 (59)

BYU 2025 Key Players

Name	Position	Stats
Bear Bachmeier	QB	518 YDS (66.7%) / 4 TD / 0 INT 65 RUSH YDS / 4 RUSH TD / 21.7 RUSH YPG
LJ Martin	RB	342 YDS / 1 TD / 114 YPG / 8.6 YPC
Carsen Ryan	TE	9 REC / 146 YDS / 2 TD / 48.7 YPG
Chase Roberts	WR	11 REC / 185 YDS / 1 TD / 61.7 YPG
Jack Kelly	LB	10 TKL / 3 TFL / 3 SACK
Isaiah Glasker	LB	9 TKL / 3 TFL / 1 SACK
Faletau Satuala	DB	7 TKL / 2 TFL / 1 INT / 1 PD
Evan Johnson	DB	6 TKL / 0 TFL / 2 INT / 2 PD

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	565 YDS (66.7%) / 4 TD / 0 INT 154 RUSH YDS / 3 RUSH TD / 51.3 RUSH YPG
Sincere Brown	WR	7 REC / 203 YDS / 2 TD / 50.8 YPG
Dekalon Taylor	RB	83 YDS / 0 TD / 20.8 YPG / 4.4 YPC 10 REC / 106 REC YDS / 2 REC TD / 35.3 REC YPG
Joseph Williams	WR	9 REC / 164 YDS / 2 TD / 41 YPG
Martavius French	LB	13 TKL / 2 TFL / 1 SACK
Keaten Wade	DL	12 TKL / 3 TFL / 1.5 SACK
Tawfiq Byard	DB	18 TKL / 1 TFL / 0.5 SACK
Jeremiah Brown	LB	13 TKL / 1 TFL