Purdue vs. Iowa State Prediction, How to Watch, Odds, Channel - Dec 6

The No. 1 Purdue Boilermakers (8-0) bring an eight-game win streak into a home matchup with the No. 10 Iowa State Cyclones (8-0), winners of eight straight as well. The contest starts at 12 p.m. ET (on CBS) on Saturday, December 6, 2025.

The Boilermakers head into their game against the Cyclones as a 5.5-point favorite. The matchup features an over/under of 153.5.

Keep reading to get the details ahead of betting on the Purdue-Iowa State game.

Purdue vs. Iowa State How to Watch & Odds

• When: Saturday, December 6, 2025 at 12 p.m. ET
• Where: Mackey Arena in West Lafayette, Indiana
• TV: CBS
• Live Box Score: FOX Sports

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Purdue vs. Iowa State Prediction

• Pick ATS: Purdue (-5.5)
  
• Pick OU: Over (153.5)
  
• Prediction: Purdue 83, Iowa State 76

Learn more about the Purdue Boilermakers vs. the Iowa State Cyclones game on FOX Sports!

Purdue vs. Iowa State Betting Insights

Betting Line Implied Predictions

• Per the spread and over/under, the implied score for the matchup is Boilermakers 80, Cyclones 74.
• The Boilermakers have a 72.9% chance to win this meeting per the moneyline's implied probability.
• The Cyclones sit with a 31.5% implied probability to win.

Key Spread Facts

• Purdue is 4-4-0 ATS this season.
• Iowa State has won six games against the spread this season, while failing to cover twice.
• Purdue has covered the spread twice when favored by 5.5 points or more this season (in six opportunities).

Key Total Facts

• Boilermakers games have finished with more than 153.5 points four times so far this season.
• Cyclones games have finished with over 153.5 points scored five times this season.
• The Boilermakers and Cyclones combine to average 184.9 points per contest, which is 31.4 more than the total for this game.

Key Moneyline Facts

• Purdue has not lost when playing as the moneyline favorite this season, going 6-0.
• Iowa State has not played a game this season while listed as the underdog.
• Purdue has won all five games it played as a moneyline favorite with odds of -269 or shorter.
• Iowa State has not entered a game this season with longer moneyline odds than +217.

Purdue vs. Iowa State: 2025-26 Stats Comparison

Purdue 2025-26 Key Players

Iowa State 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Purdue Boilermakers

Iowa State Cyclones