Purdue vs. Iowa State Prediction, How to Watch, Odds, Channel - Dec 6

Updated Dec. 6, 2025 10:27 a.m. ET

Data Skrive

The No. 1 Purdue Boilermakers (8-0) bring an eight-game win streak into a home matchup with the No. 10 Iowa State Cyclones (8-0), winners of eight straight as well. The contest starts at 12 p.m. ET (on CBS) on Saturday, December 6, 2025.

The Boilermakers head into their game against the Cyclones as a 5.5-point favorite. The matchup features an over/under of 153.5.

Keep reading to get the details ahead of betting on the Purdue-Iowa State game.

Purdue vs. Iowa State How to Watch & Odds

When: Saturday, December 6, 2025 at 12 p.m. ET
Where: Mackey Arena in West Lafayette, Indiana
TV: CBS
Live Box Score: FOX Sports

Boilermakers vs Cyclones Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Boilermakers	-5.5	-115	-106	153.5	-110	-110	-269	+217

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Purdue vs. Iowa State Prediction

Pick ATS: Purdue (-5.5)
Pick OU: Over (153.5)
Prediction: Purdue 83, Iowa State 76

Learn more about the Purdue Boilermakers vs. the Iowa State Cyclones game on FOX Sports!

Purdue vs. Iowa State Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the matchup is Boilermakers 80, Cyclones 74.
The Boilermakers have a 72.9% chance to win this meeting per the moneyline's implied probability.
The Cyclones sit with a 31.5% implied probability to win.

Key Spread Facts

Purdue is 4-4-0 ATS this season.
Iowa State has won six games against the spread this season, while failing to cover twice.
Purdue has covered the spread twice when favored by 5.5 points or more this season (in six opportunities).

Key Total Facts

Boilermakers games have finished with more than 153.5 points four times so far this season.
Cyclones games have finished with over 153.5 points scored five times this season.
The Boilermakers and Cyclones combine to average 184.9 points per contest, which is 31.4 more than the total for this game.

Key Moneyline Facts

Purdue has not lost when playing as the moneyline favorite this season, going 6-0.
Iowa State has not played a game this season while listed as the underdog.
Purdue has won all five games it played as a moneyline favorite with odds of -269 or shorter.
Iowa State has not entered a game this season with longer moneyline odds than +217.

Purdue vs. Iowa State: 2025-26 Stats Comparison

	Purdue	Iowa State
Points Scored Per Game (Rank)	88.6 (36)	96.3 (4)
Points Allowed (Rank)	67.6 (73)	65.4 (33)
Rebounds (Rank)	12.3 (35)	9.9 (167)
3pt Made (Rank)	10.5 (36)	10.1 (47)
Assists (Rank)	20.6 (5)	19.3 (17)
Turnovers (Rank)	9.1 (23)	9.6 (44)

Purdue 2025-26 Key Players

Boilermakers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Fletcher Loyer	8	15.6	2.4	1.5	0.9	0.0	3.3
Trey Kaufman-Renn	6	15.5	11.0	2.5	0.7	0.2	0.2
Braden Smith	8	13.4	3.5	8.8	1.0	0.0	2.0
Oscar Cluff	8	11.3	9.3	2.1	0.3	1.0	0.0
Daniel Jacobsen	8	9.4	4.9	0.6	0.3	2.4	0.3

Iowa State 2025-26 Key Players

Cyclones Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Tamin Lipsey	5	18.4	3.6	5.2	3.2	0.2	1.6
Joshua Jefferson	8	18.4	7.3	5.6	1.5	0.5	0.8
Milan Momcilovic	8	18.1	3.1	1.4	1.5	0.0	4.3
Killyan Toure	8	11.9	2.6	2.6	2.3	0.3	0.8
Blake Buchanan	8	8.5	5.3	1.5	1.0	1.1	0.0