Louisville vs. Indiana Prediction, How to Watch, Odds, Channel - Dec 6

Updated Dec. 6, 2025 3:27 p.m. ET

Data Skrive

The No. 22 Indiana Hoosiers (7-1) will look to extend a six-game home win streak when they host the No. 6 Louisville Cardinals (7-1) on Saturday, December 6, 2025 at Gainbridge Fieldhouse. The contest airs at 2:15 p.m. ET on CBS.

The Cardinals head into their game as a 3.5-point favorite against the Hoosiers. The point total for the game is 160.5.

Keep scrolling to get the details ahead of wagering on the Louisville-Indiana matchup.

Louisville vs. Indiana How to Watch & Odds

When: Saturday, December 6, 2025 at 2:15 p.m. ET
Where: Gainbridge Fieldhouse in Indianapolis, Indiana
TV: CBS
Live Box Score: FOX Sports

Cardinals vs Hoosiers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cardinals	-3.5	-111	-109	160.5	-110	-110	-177	+148

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Louisville vs. Indiana Prediction

Pick ATS: Indiana (+3.5)
Pick OU: Under (160.5)
Prediction: Indiana 79, Louisville 77

Learn more about the Louisville Cardinals vs. the Indiana Hoosiers game on FOX Sports!

Louisville vs. Indiana Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Cardinals 82, Hoosiers 78.
The Cardinals have a 63.9% chance to claim victory in this game based on the moneyline's implied probability.
The Hoosiers sit with a 40.3% implied probability to come out on top.

Key Spread Facts

Louisville has compiled a 5-3-0 record against the spread this season.
Indiana has won five games against the spread this year, while failing to cover three times.
Louisville is 5-2 ATS this season when playing as at least 3.5-point favorites.

Key Total Facts

The Cardinals games have had more than 160.5 points scored on four occasions this season.
Hoosiers games have finished with over 160.5 points only two times this year.
These teams score 181 points per game combined, higher than the over/under for this matchup by 20.5.

Key Moneyline Facts

Louisville is 6-1 in games when it was favored on the moneyline (winning 85.7%).
Indiana has not played a game this season while listed as the underdog.
Louisville has won all six games it played as a moneyline favorite with odds of -177 or shorter.
Indiana has not entered a game this season with longer moneyline odds than +148.

Louisville vs. Indiana: Recent Results

Cardinals vs Hoosiers Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
11/27/2024	Hoosiers	-3.5	154.5	-172	+144	89-61 LOU

Louisville vs. Indiana: 2025-26 Stats Comparison

	Louisville	Indiana
Points Scored Per Game (Rank)	94.6 (7)	86.4 (57)
Points Allowed (Rank)	66.3 (50)	63.8 (16)
Rebounds (Rank)	13.1 (9)	8.1 (296)
3pt Made (Rank)	12.6 (3)	10.3 (39)
Assists (Rank)	19.8 (10)	20.0 (7)
Turnovers (Rank)	10.3 (72)	8.9 (16)

Louisville 2025-26 Key Players

Cardinals Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Ryan Conwell	8	19.5	4.9	2.6	1.3	0.0	3.9
Mikel Brown Jr.	8	17.6	3.5	5.6	0.9	0.0	2.1
Isaac McKneely	8	12.1	3.6	0.8	0.5	0.3	3.1
Sananda Fru	8	10.4	6.1	1.0	0.3	1.3	0.1
J'Vonne Hadley	7	9.0	5.7	1.4	0.6	0.4	1.0

Indiana 2025-26 Key Players

Hoosiers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Tucker DeVries	8	16.8	5.1	3.4	1.0	0.6	3.6
Lamar Wilkerson	8	16.5	2.6	2.3	1.6	0.3	2.9
Tayton Conerway	8	12.6	3.3	4.9	2.1	0.4	0.8
Reed Bailey	8	10.6	4.1	2.0	0.4	0.5	0.1
Sam Alexis	8	10.5	6.0	1.3	0.4	1.3	0.1