Iowa State vs. Creighton Prediction, How to Watch, Odds, Channel - Nov 25

The Creighton Bluejays (3-2) will attempt to continue a three-game home winning streak when they host the No. 15 Iowa State Cyclones (5-0) on Tuesday, November 25, 2025 at Michelob ULTRA Arena. The contest airs at 2 p.m. ET on truTV.

The Cyclones are a 5.5-point favorite against the Bluejays when the Cyclones and the Bluejays square off. The point total for the game is set at 151.5.

Keep reading to get all you need to know ahead of betting on the Iowa State-Creighton contest.

Iowa State vs. Creighton How to Watch & Odds

• When: Tuesday, November 25, 2025 at 2 p.m. ET
• Where: Michelob ULTRA Arena in Las Vegas, Nevada
• TV: truTV
• Live Box Score: FOX Sports

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Iowa State vs. Creighton Prediction

• Pick ATS: Iowa State (-5.5)
  
• Pick OU: Over (151.5)
  
• Prediction: Iowa State 82, Creighton 71

Learn more about the Iowa State Cyclones vs. the Creighton Bluejays game on FOX Sports!

Iowa State vs. Creighton Betting Insights

Betting Line Implied Predictions

• Based on the spread and over/under, the implied score for the encounter is Cyclones 78, Bluejays 73.
• The Cyclones have a 73.8% chance to collect the win in this game per the moneyline's implied probability.
• The Bluejays have a 30.5% implied probability to come out on top.

Key Spread Facts

• Iowa State has won three games against the spread this season, while failing to cover twice.
• Creighton has covered just once in five matchups with a spread this year.
• When playing as at least 5.5-point favorites this season, Iowa State has an ATS record of 3-1.
• Creighton has not covered the spread when an underdog by 5.5 points or more this season (in one opportunity).

Key Total Facts

• Four times so far this year, the Cyclones and their opponent have combined to score more than 151.5 points.
• Bluejays games have finished with over 151.5 points scored three times this year.
• The Cyclones and Bluejays average 170.6 points per game combined, which is 19.1 more than the over/under for this matchup.

Key Moneyline Facts

• Iowa State has not lost as the moneyline favorite this season, going 3-0.
• Creighton has lost both games it has played as underdogs this season.
• Iowa State has played as a moneyline favorite of -282 or shorter in only one game this season, and won.
• Creighton has played as an underdog of +228 or more once this season and lost that game.

Iowa State vs. Creighton: 2025-26 Stats Comparison

Iowa State 2025-26 Key Players

Creighton 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Big East

Creighton Bluejays

Iowa State Cyclones