Butler vs. South Carolina Prediction, How to Watch, Odds, Channel - Nov 21

The South Carolina Gamecocks (4-0) will look to extend a four-game win streak when they hit the road to take on the Butler Bulldogs (3-1) on Friday, November 21, 2025 at Colonial Hall. The matchup airs at 2 p.m. ET on CBS Sports Network.

The Bulldogs are a 3.5-point favorite against the Gamecocks when the Bulldogs and Gamecocks play. The over/under for the game is set at 150.5.

Keep reading to get the download before placing bets on the Butler-South Carolina contest.

Butler vs. South Carolina How to Watch & Odds

• When: Friday, November 21, 2025 at 2 p.m. ET
• Where: Colonial Hall in White Sulphur Springs, West Virginia
• TV: CBS Sports Network
• Live Box Score: FOX Sports

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Butler vs. South Carolina Prediction

• Pick ATS: Pick Em
  
• Pick OU: Over (150.5)
  
• Prediction: Butler 82, South Carolina 79

Learn more about the Butler Bulldogs vs. the South Carolina Gamecocks game on FOX Sports!

Butler vs. South Carolina Betting Insights

Betting Line Implied Predictions

• Per the spread and over/under, the implied score for the encounter is Bulldogs 77, Gamecocks 74.
• The Bulldogs have a 64.7% chance to claim victory in this meeting per the moneyline's implied probability.
• The Gamecocks hold a 39.7% implied probability to come out on top.

Key Spread Facts

• Butler compiled a 17-18-0 record against the spread last season.
• South Carolina covered 16 times in 32 chances against the spread last season.
• When playing as at least a 3.5-point favorite last season, Butler had an ATS record of 6-6.
• South Carolina was an underdog by 3.5 points or more 17 times last year, and covered the spread in eight of those matchups.

Key Total Facts

• The Bulldogs games had more than 150.5 points on 15 occasions last year.
• There were seven Gamecocks games last year with more than 150.5 points scored.
• Last season, the two teams averaged a combined 144.5 points per contest, 6.0 fewer than the total for this matchup.

Key Moneyline Facts

• Butler won 78.6% of the games last season in which it was favored on the moneyline (11-3).
• Last season, South Carolina was the underdog 20 times and won two of those games.
• When it played as a moneyline favorite with odds of -183 or shorter last year, Butler finished with a record of 9-2 (81.8%).
• South Carolina did not win as an underdog of +152 or more on the moneyline last season in 17 games with those odds or longer.

Butler vs. South Carolina: 2024-25 Stats Comparison

Butler 2024-25 Top Performers

South Carolina 2024-25 Top Performers

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Big East

Butler Bulldogs

South Carolina Gamecocks