Swansea boss Brendan Rodgers has almost a full squad to select from against the Gunners.
Rodgers is set to make changes from the side that beat Barnsley in the FA Cup with the likes of Michel Vorm, Joe Allen, Steven Caulker and Scott Sinclair likely to return to the starting line-up, while Gylfi Sigurdsson could be handed a full debut in midfield.
Long-term absentee Alan Tate is on the comeback trail after featuring for the reserves in midweek, four months after suffering a broken leg, but is a few weeks away from a return to first-team action.
Arsenal captain Robin van Persie will return to the squad following an extended break.
Thierry Henry, on loan from the New York Red Bulls, will again be in contention having come off the bench to score in the FA Cup win over Leeds, while defender Johan Djourou is available after suspension.
Midfielder Tomas Rosicky and centre-back Per Mertesacker are battling to overcome a virus.
Strikers Marouane Chamakh and Gervinho are away at the African Nations Cup. Defenders Thomas Vermaelen (calf), Kieran Gibbs (groin), Bacary Sagna (ankle), Carl Jenkinson (back) and Andre Santos (ankle) are all still out, along with midfielders Francis Coquelin, Abou Diaby (both hamstring) and Jack Wilshere (ankle).
Swansea (from): Vorm, Williams, Taylor, Caulker, Britton, Orlandi, Graham, Sinclair, Dyer, Dobbie, Routledge, Monk, Lita, Moore, Bessone, Rangel, Allen, Tremmel, Agustien, Gower, Richards, Alfei, Donnelly, Sigurdsson, Situ.
Arsenal (from): Szczesny, Koscielny, Djourou, Mertesacker, Miquel, Song, Ramsey, Arteta, Walcott, Van Persie, Henry, Almunia, Rosicky, Arshavin, Squillaci, Benayoun, Oxlade-Chamberlain, Park.
