Mexico opened World Cup qualifying with a 3-1 win over Guyana on Friday night, getting goals from Carlos Salcido and Giovani dos Santos during a five-minute span early in the first half.
Salcido put El Tri in front in the 11th minute at Mexico City's Azteca Stadium, and dos Santos doubled the lead in the 15th with his 14th goal in 58 international appearances.
An own goal by John Rodrigues gave Mexico a three-goal lead in the 51st, but Mexico's Hector had an own-goal nine minutes later.
El Salvador was at Costa Rica in the other Group B match in North and Central America and the Caribbean's semifinal round.
In Group C, Olivier Occean scored on a header off a cross from David Edgar in the 55th minute to give Canada a 1-0 win over Cuba at Havana. The Canadians played a man short after goalkeeper Lars Hirschfeld was given a red card in the 64th minute for handling the ball outside his penalty area.
In the other Group C match, Honduras hosted Panama.
The United States beat Antigua and Barbuda 3-1 in Group A on goals by Carlos Bocanegra, Clint Dempsey and Herculez Gomez, with Peter Byers scoring in the second half for the visitors. Guatemala was at Jamaica.
The top two teams in each CONCACAF group advance to next year's regional finals, which will produce three qualifiers for the 2014 tournament in Brazil.
In Asia, Keisuke Honda scored a hat trick as Japan routed Jordan 6-0, and Australia stumbled to a 0-0 draw against Oman. South Korea routed 2022 World Cup host Qatar 4-1, and Lebanon and Uzbekistan drew 1-1.
