Defender Jose Enrique is set to return to Liverpool's starting line-up.
The Spaniard was left out for tactical reasons in the Carling Cup semi-final first leg win over Manchester City but is likely to return.
Midfielder Jay Spearing sustained a minor hamstring injury in midweek and that is likely to allow Charlie Adam to regain his place.
Stoke manager Tony Pulis has concerns over a number of players ahead of the trip.
Defenders Jonathan Woodgate, Marc Wilson and Ryan Shotton are all nursing what Pulis describes as "niggles" and will be assessed.
Andy Wilkinson could return at the back having overcome his recent knee injury, while the likes of goalkeeper Thomas Sorensen, winger Matthew Etherington and striker Peter Crouch are set to be restored to the team after they were rested for last weekend's FA Cup victory at Gillingham.
Liverpool (from): Reina, Johnson, Skrtel, Agger, Enrique, Adam, Gerrard, Kuyt, Henderson, Downing, Carroll, Doni, Kelly, Carragher, Coates, Shelvey, Rodriguez, Bellamy.
Stoke (from): Sorensen, Wilkinson, Huth, Shawcross, Wilson, Pennant, Delap, Palacios, Etherington, Crouch, Walters, Begovic, Shotton, Upson, Diao, Jones, Whitehead, Whelan, Woodgate, Fuller, Higginbotham, Jerome.