Arsenal striker Thierry Henry (calf) faces a fitness test ahead of kick-off.
Defender Thomas Vermaelen (calf) is a major doubt, while midfielder Mikel Arteta (calf) is not fit.
Strikers Marouane Chamakh and Gervinho are away at the African Nations Cup. Defenders Francis Coquelin (hamstring), Kieran Gibbs (groin), Bacary Sagna (ankle), Carl Jenkinson (back) and Andre Santos (ankle) are all still out, along with midfielders Abou Diaby (hamstring) and Jack Wilshere (ankle).
United are set to welcome back England duo Chris Smalling and Phil Jones.
The pair both missed last weekend's win over Bolton after suffering minor injuries in a collision during the Manchester derby.
Brazilian midfielder Anderson has been ruled out after suffering a training ground injury, whilst Tom Cleverley (ankle) and Ashley Young (knee) should be back in full training within 10 days.
Arsenal (from): Szczesny, Koscielny, Djourou, Mertesacker, Miquel, Song, Ramsey, Arshavin, Walcott, van Persie, Henry, Almunia, Rosicky, Arshavin, Squillaci, Benayoun, Oxlade-Chamberlain, Park, Yennaris.
Man United (from): De Gea, Lindegaard, Amos, Smalling, Rafael, Ferdinand, Evra, Jones, Evans, Fryers, Cole, Carrick, Scholes, Valencia, Park, Nani, Giggs, Rooney, Welbeck, Berbatov, Hernandez, Diouf.
