Aberdeen have major doubts over midfield duo Peter Pawlett and Isaac Osbourne ahead of the game after they went off in the first half of last weekend's Scottish Cup win at Forfar with hamstring injuries.
Striker Scott Vernon is likely to feature despite suffering a dead leg at Forfar, while midfielder Rob Milsom and defender Youl Mawene are doubts with undisclosed injuries.
Kilmarnock have eight players out: goalkeeper Anssi Jaakkola, defenders Alex Pursehouse and Ryan O'Leary (all knee), midfielders Gary Fisher (foot), David Silva (groin), Gary Harkins (ankle) plus James Dayton and Danny Buijs (both hamstring).
Goalkeeper Kyle Letheren and teenagers Chris Johnston, Ross Davidson and Lee Ashcroft come into the squad along with new signings Ben Gordon and Michael Nelson.
Aberdeen (from): Brown, Jack, Mackie, Pawlett, Clark, Arnason, Osbourne, Vernon, Fallon, Magennis, Gonzalez, McArdle, Robertson, Megginson, Grimmer, Fyvie, Chalali, Reynolds, Langfield.
Kilmarnock (from): Bell, Hay, Gordon, Sissoko, Pascali, Kroca, Shiels, Fowler, Racchi, Kelly, Heffernan, Kennedy, Ashcroft, Gros, McKeown, Nelson, Davidson, Johnston, Letheren.