2025-26 NBA Playoff Odds: Spreads, Lines for Second-Round Series

Now the NBA playoffs are in the swing of things.

Let's check out the odds for the second round of the playoffs, at DraftKings Sportsbook as of May 14.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

EAST SECOND ROUND

No. 7 PHILADELPHIA vs. No. 3 NEW YORK
NYK wins 4-0

No. 4 CLEVELAND (-320) vs. No. 1 DETROIT (+260) 
CLE leads 3-2

GAME 6 — DET @ CLE (May 15)

Spread: Cavs -3.5
Moneyline: Cavs -180, Pistons +150
O/U: 209.5

What to know: The top-seeded Pistons are in trouble once again. After coming back from a 3-1 deficit against Orlando in Round 1, they are now down 3-2 to the Cavs, with Game 6 going down in Cleveland. The Cavs have yet to lose a home game this postseason, and their win over the Pistons in Detroit was their first road win of the playoffs. Detroit will need to win two straight in order to stay alive. 

WEST SECOND ROUND

No. 4 LOS ANGELES vs. No. 1 OKLAHOMA CITY
OKC wins 4-0

No. 6 MINNESOTA (+750) vs. No. 3 SAN ANTONIO (-1200) 
SAS leads 3-2

GAME 6 — SAS @ MIN (May 15)

Spread: Spurs -4.5
Moneyline: Spurs -192, Wolves +160
O/U: 218.5

What to know: In a back-and-forth series, the Spurs won Game 5 at home to put the Wolves on the brink of elimination. Fresh off an ejection in Game 4, Wemby returned to the lineup and dominated for San Antonio, putting up 27 points, 15 rebounds, five assists and three blocks. Things will now shift back to Minnesota, where the Wolves will look to put this thing to seven.