Seahawks vs. Saints 2025 Prediction, Odds, Picks - Sep 21

The Seattle Seahawks (1-1) are favored by 7.5 points versus the New Orleans Saints (0-2) on September 21, 2025, starting at 4:05 p.m. ET, airing on CBS. An over/under of 41.5 points has been set for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

Seahawks vs. Saints Odds & Betting Lines

Seahawks vs. Saints Prediction & Pick

• Pick ATS: Seahawks (-7.5)
  
• Pick OU: Over (41.5)
  
• Prediction: Seahawks 28 - Saints 16

How to Watch Seattle vs. New Orleans

• Game date: Sunday, September 21, 2025
• Time: 4:05 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: CBS
• Live Boxscore: FOX Sports

Seahawks vs. Saints Recent Matchups

• In their past three head-to-head matchups, New Orleans has beaten Seattle three times.
• Over their last three head-to-head matchups, New Orleans has scored 85 points, while Seattle has accumulated 69.

Seattle Betting Info

• Seattle has one win against the spread in two games this season.
• Seattle's games this year have hit the over one time in two opportunities (50%).
• This is the first matchup the Seahawks are moneyline favorites this season.
• The implied probability for this matchup, considering the moneyline, gives the Seahawks a 78.9% chance to win.

Seahawks Stats

Seattle's Key Players

Offense

• Sam Darnold has thrown for 445 yards, two touchdowns and two interceptions this year. He averages 222.5 yards per game and 7.9 per attempt, while completing 67.9% of his attempts.
• Jaxon Smith-Njigba has caught 17 passes (third in the NFL) on 23 targets for 227 total yards (second in the NFL) and zero touchdowns. He is averaging 8.5 catches and 113.5 yards per game in two games.
• In two games, Kenneth Walker III has amassed 125 yards on the ground, averaging 62.5 yards per game and scoring one touchdown.
• Zach Charbonnet has rushed for 57 yards with one touchdown (28.5 yards per game across two games).

Defense

• On defense, Ernest Jones has one interception (third in the NFL) to go with 18 tackles, 1.0 TFL, and two passes defended in 2025.
• Julian Love has 1.0 sack (second on the Seahawks) to go with 1.0 TFL and 12 tackles.
• Byron Murphy has put up 11 tackles, 1.0 TFL, and 1.5 sacks.
• Coby Bryant has 11 tackles and one interception on the year.

New Orleans Betting Info

• New Orleans has not covered the spread in any game this season (0-2-0).
• Games involving New Orleans have hit the over once this season.
• The Saints have lost both games they've played as underdogs this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Saints have a 25.3% chance to win.

Saints Stats

New Orleans' Key Players

Offense

• Spencer Rattler is averaging 5.3 passing yards per attempt (32nd in the NFL) and 210.5 yards per game this year, completing 65.0% of his passes on the way to 421 total yards, three touchdowns and zero interceptions through two games.
• He's added 43 yards on the ground (second on the Saints), while scoring zero rushing touchdowns. He's averaging 21.5 yards per game and 5.4 per attempt.
• Alvin Kamara has scored one rushing touchdown, while totaling 144 rushing yards (4.5 per attempt and 72.0 per game).
• Kamara has also picked up 33 receiving yards (16.5 per game) on eight catches (4.0 per game). He's been targeted eight times and is still trying for his first receiving touchdown.
• Juwan Johnson has registered 125 receiving yards and one touchdown on 13 receptions, while being targeted 20 times this season.
• Rashid Shaheed has 85 receiving yards and one touchdown from 10 receptions after receiving 14 targets.

Defense

• Carl Granderson's 2025 output includes 13 tackles, 4.0 TFL, and 3.5 sacks in two games. He is third on the Saints in tackles.
• Demario Davis' stats include 20 tackles and 2.0 TFL.
• Pete Werner has 14 tackles, 1.0 TFL, one sack, and two passes defended during the 2025 season.
• Alontae Taylor has put up 1.0 sack (third on the Saints) to go with 2.0 TFL and eight tackles through two games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Seattle Seahawks

New Orleans Saints