Seahawks vs. 49ers 2025 Divisional Round Prediction, Odds, Picks - Jan 17

In the NFC Divisional round of the 2025 NFL Playoffs, the Seattle Seahawks will match up against the San Francisco 49ers. The Seahawks are solid favorites, expected to win by at least a touchdown (currently -7). The game has an over/under of 44.5 points.

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Seahawks vs. 49ers Odds & Betting Lines

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Seahawks vs. 49ers Prediction & Pick

• Pick ATS: Seahawks (-7)
  
• Pick OU: Over (44.5)
  
• Prediction: Seahawks 28 - 49ers 19

How to Watch Seattle vs. San Francisco

• Game date: Saturday, January 17, 2026
• Time: 8 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Seahawks vs. 49ers Recent Matchups

• San Francisco holds a 3-2 record against Seattle in their last five matchups.
• Over their last five head-to-head matchups, San Francisco has put up 101 points, while Seattle has posted 86.

Seattle Betting Info

• Seattle is 12-5-0 against the spread this year.
• The Seahawks have covered the spread twice this season (2-2 ATS) when playing as at least 7-point favorites.
• Seattle has combined with its opponent to hit the over in 52.9% of its contests this year (nine times over 17 games with a set point total).
• The Seahawks have a 13-1 record in games they played as the moneyline favorite (winning 92.9% of those games).
• Based on this matchup's moneyline, the Seahawks' implied win probability is 77.5%.

Seahawks Stats

Seattle's Key Players

Offense

• Jaxon Smith-Njigba's 1,793 receiving yards this season (first in the NFL) have come from 119 receptions (fourth in the NFL) on 163 targets. He's averaging 7.0 catches and 105.5 yards per game, with 10 receiving touchdowns (sixth in the NFL).
• Sam Darnold has 4,048 passing yards (fifth in the NFL), 25 touchdowns (ninth in the NFL) and 14 interceptions this year. He has completed 67.7% of his attempts, averaging 238.1 yards per game and 8.5 per attempt.
• Through 16 games, Zach Charbonnet has amassed 730 yards on the ground, averaging 45.6 yards per game and scoring 12 touchdowns.
• Kenneth Walker III has rushed for 1,027 yards with five touchdowns (60.4 yards per game through 17 games).
• Walker has been targeted 36 times and turned those targets into 31 receptions, 282 yards and zero TDs.

Defense

• On defense, Ernest Jones has five interceptions (second in the NFL) to go with 126 tackles, 4.0 TFL, 0.5 sacks, and seven passes defended in 2025.
• Drake Thomas has 88 tackles, 10.0 TFL, 3.5 sacks, and one interception this season. He's second on the Seahawks in tackles.
• This season, Demarcus Lawrence has put up 6.0 sacks (fourth on the Seahawks) to go along with his 11.0 TFL and 53 tackles.
• So far this season, Nick Emmanwori has 81 tackles, 9.0 TFL, 2.5 sacks, and one interception. He's third on the Seahawks in tackles.

San Francisco Betting Info

• San Francisco's record against the spread in the regular season was 11-6-0. It has an ATS record of 1-0-0 in the playoffs.
• The 49ers have covered every time (1-0) as 7-point underdogs or more in the regular season and playoffs.
• San Francisco had 10 of its 17 games hit the over during the regular season. It has topped the over in zero of one playoff games.
• During the regular season, the 49ers won one out of five games in which they were the underdogs. They are 1-0 in the playoffs.
• The implied probability of a win by the 49ers based on the moneyline is 26.7%.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey averages 70.7 rushing yards per game this year (1,202 total yards to rank eighth in the NFL), while scoring 10 rushing touchdowns.
• McCaffrey has also figured into the receiving game with 924 yards (54.4 per game) on 102 receptions (6.0 per game), while being targeted 129 times. He has seven receiving touchdowns.
• Brock Purdy has 2,167 passing yards, 20 touchdowns and 10 interceptions. His completion percentage is 69.4% and he averages 240.8 yards per game and 7.6 per attempt.
• Purdy also has three rushing touchdowns and 147 rushing yards (third on the 49ers).
• Mac Jones has passed for 2,151 yards this year, 13 touchdowns and six interceptions. He is completing 69.6% of his passes while averaging 195.5 yards per game and 7.4 per attempt.
• Jauan Jennings has been targeted 90 times, resulting in 55 catches for 643 yards (eighth in the NFL).

Defense

• Dee Winters' 2025 output includes 101 tackles, 8.0 TFL, and one interception through 17 games. He leads the 49ers in tackles.
• Upton Stout has 1.0 sack in addition to his 4.0 TFL and 82 tackles over 16 games.
• Ji'Ayir Brown has 63 tackles, 2.0 TFL, and two interceptions in the 2025 campaign. He is fifth on the 49ers in tackles.
• Malik Mustapha's season stats include 76 tackles, 3.0 TFL, and one interception through 12 games. He is fourth on the 49ers in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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