Seahawks vs. 49ers 2025 Divisional Round Prediction, Odds, Picks - Jan 17

The Seattle Seahawks and San Francisco 49ers will feature in the NFC Divisional round of the 2025 NFL Playoffs. The Seahawks are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6.5). An over/under of 44.5 points has been set for the matchup.

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Seahawks vs. 49ers Odds & Betting Lines

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Seahawks vs. 49ers Prediction & Pick

• Pick ATS: Seahawks (-6.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Seahawks 28 - 49ers 19

How to Watch Seattle vs. San Francisco

• Game date: Saturday, January 17, 2026
• Time: 8 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Seahawks vs. 49ers Recent Matchups

• Over their last five meetings, San Francisco has tallied three wins against Seattle.
• Over their last five head-to-head contests, San Francisco has scored 101 points, while Seattle has posted 86.

Seattle Betting Info

• Seattle is 12-5-0 against the spread this season.
• The Seahawks have an ATS record of 5-2 when playing as at least 6.5-point favorites this season.
• Seattle games in 2025 have hit the over nine times in 17 opportunities (52.9%).
• When playing as moneyline favorites, the Seahawks are 13-1 (winning 92.9% of the time).
• Looking at this contest's moneyline, the Seahawks' implied win probability is 74.0%.

Seahawks Stats

Seattle's Key Players

Offense

• Jaxon Smith-Njigba has brought in 119 passes (fourth in the NFL) on 163 targets for 1,793 total yards (first in the NFL) and 10 touchdowns. He is averaging 7.0 catches and 105.5 yards per game over 17 games played.
• Sam Darnold has passed for 4,048 yards (fifth in the NFL), 25 touchdowns (ninth in the NFL) and 14 interceptions this year. He averages 238.1 yards per game and 8.5 per attempt, while completing 67.7%.
• Zach Charbonnet has 730 rushing yards with 12 touchdowns (45.6 yards per game across 16 games).
• In the ground game, Kenneth Walker III averages 4.6 yards per attempt (16th in the NFL) and 60.4 yards per game for 1,027 total rushing yards. He has recorded five rushing touchdowns this season.
• He has added 31 catches (on 36 targets) for 282 receiving yards with zero touchdowns. He's averaging 16.6 receiving yards and 1.8 receptions per game.

Defense

• Over on defense, Ernest Jones has five interceptions (second in the NFL) to go with 126 tackles, 4.0 TFL, 0.5 sacks, and seven passes defended in 2025.
• Drake Thomas has 88 tackles, 10.0 TFL, 3.5 sacks, and one interception this season.
• Demarcus Lawrence has recorded 53 tackles, 11.0 TFL, and six sacks this year.
• Nick Emmanwori has one interception while also adding 81 tackles, 9.0 TFL, 2.5 sacks, and 11 passes defended.

San Francisco Betting Info

• San Francisco's record against the spread in the regular season was 11-6-0. It has an ATS record of 1-0-0 in the playoffs.
• The 49ers have covered every time (1-0) as 6.5-point underdogs or more in the regular season and playoffs.
• Out of 17 San Francisco games in the regular season, 10 hit the over. As for the postseason, zero of one games have exceeded the over.
• The 49ers were underdogs in five games during the regular season and won one (20%) of those contests. They've gone 1-0 in the playoffs.
• The bookmakers' moneyline implies a 30.3% chance of a victory for the 49ers.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey has rushed for 10 touchdowns this year, and has 1,202 total rushing yards (70.7 per game and 3.9 per carry).
• McCaffrey has also played a role the passing game with 924 yards (54.4 per game) on 102 receptions (6.0 per game), while being targeted 129 times. He has seven receiving touchdowns.
• Brock Purdy has 2,167 passing yards, 20 touchdowns and 10 interceptions. His completion percentage is 69.4% and he averages 240.8 yards per game and 7.6 per attempt.
• Purdy also has three rushing touchdowns and 147 rushing yards (third on the 49ers).
• Mac Jones has thrown for 2,151 yards this year, 13 touchdowns and six interceptions. He is completing 69.6% of his attempts while averaging 195.5 yards per game and 7.4 per attempt.
• Jauan Jennings has 55 catches for 643 yards and nine receiving touchdowns (eighth in the NFL). He averages 3.7 yards per game in 15 games and has been targeted 90 times.

Defense

• Dee Winters' 2025 showing includes 101 tackles, 8.0 TFL, and one interception in 17 games. He leads the 49ers in tackles.
• Upton Stout has 1.0 sack to go with 4.0 TFL and 82 tackles.
• Ji'Ayir Brown has 2.0 TFL, 63 tackles, and two interceptions in the 2025 campaign.
• Malik Mustapha has intercepted one pass and also has 76 tackles, 3.0 TFL, and three passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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