How to Watch Colts vs. 49ers: Time, TV Channel and Live Stream – 2025 Week 16

The San Francisco 49ers (10-4) visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET, in a battle featuring a pair of the top offensive players in the league in Christian McCaffrey and Jonathan Taylor.

Offensively, the 49ers rank 10th in the NFL with 347.5 yards per game. Meanwhile, they rank 18th in total defense (333.6 yards allowed per contest). The Colts are putting up 357.9 total yards per game on offense this season (seventh-ranked). Meanwhile, they are surrendering 342.7 total yards per game (22nd-ranked).

Below we dig deep into all of the info you need before this contest starts, including how to watch on TV.

Check out the full NFL schedule on FOX Sports! Or visit FOX Sports' NFL hub for everything you need to make the most of this season’s action.

How to Watch Colts vs. 49ers

• When: Monday, December 22, 2025 at 8:15 p.m. ET
• Where: Lucas Oil Stadium in Indianapolis, Indiana
• TV: ESPN
• Streaming: FOX One + ESPN Bundle

Learn more about the San Francisco 49ers vs. the Indianapolis Colts on FOX Sports!

49ers vs. Colts: Head-to-Head

• In the past two meetings, Indianapolis has a 2-0 record against San Francisco.
• San Francisco has scored 15 fewer points than Indianapolis in their past two games.

49ers' 2025 Schedule

49ers Stats & Insights

• On the offensive side of the ball, San Francisco has been a top-five unit in terms of passing yards, ranking fourth-best in the NFL by averaging 246.1 per game. The 49ers rank 22nd on defense (227.6 passing yards allowed per game).
• The 49ers rank 25th in run offense (101.4 rushing yards per game) and 12th in run defense (106.1 rushing yards allowed per game) this year.
• With 14 forced turnovers (21st in NFL) against 19 turnovers committed (23rd in NFL), San Francisco (-5) has the 26th-ranked turnover margin in the league.

49ers Key Players

• The 49ers' offense has been driven by McCaffrey, who has scampered for 922 yards (65.9 yards per carry) and nine rushing touchdowns.
• Mac Jones has suited up for 10 games in 2025, and he's totaled 2,151 passing yards, 13 touchdowns, six interceptions and a 69.6% completion percentage.
• In six games for the 49ers, Brock Purdy has delivered 1,442 yards (240.3 yards per game) with 12 touchdowns, seven interceptions and a 67.9% completion percentage.

Colts' 2025 Schedule

Colts Stats & Insights

• Indianapolis ranks ninth in passing yards per game (229), but it has been less effective defensively, ranking second-worst in the NFL with 247.6 passing yards allowed per contest.
• The Colts rank sixth in the NFL with 128.9 rushing yards per contest, but they've been carried by their defense, which ranks fifth-best by allowing just 95.1 rushing yards per game.
• Indianapolis has recorded 18 forced turnovers (ninth in NFL) and committed 16 turnovers (14th in NFL) this season for a +2 turnover margin that ranks 10th in the NFL.

Colts Key Players

• Taylor has rushed for 1,443 yards (103.1 per game) and 16 touchdowns in 14 games.
• Michael Pittman Jr. has 72 receptions for 725 yards (51.8 per game) and seven touchdowns in 14 games.
• In 14 games, Tyler Warren has 63 receptions for 718 yards (51.3 per game) and four touchdowns.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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