How to Watch Colts vs. 49ers: Time, TV Channel and Live Stream – 2025 Week 16

Updated Dec. 22, 2025 7:12 p.m. ET

FOX Sports

On Monday at 8:15 p.m. ET, two of the top offensive performers in the league will be on show when Christian McCaffrey and the San Francisco 49ers (10-4) visit Jonathan Taylor and the Indianapolis Colts (8-6).

On offense, the 49ers rank 10th in the NFL with 24.6 points per game. Meanwhile, they rank 11th in points allowed (333.6 points allowed per contest). With 28 points per game on offense, the Colts rank sixth in the NFL. Defensively, they rank 13th, surrendering 21.6 points per contest.

In the article below, we provide all the details you need to know about how to watch this game on TV.

Check out the full NFL schedule on FOX Sports! Or visit FOX Sports' NFL hub for everything you need to make the most of this season’s action.

How to Watch Colts vs. 49ers

When: Monday, December 22, 2025 at 8:15 p.m. ET
Where: Lucas Oil Stadium in Indianapolis, Indiana
TV: ESPN
Streaming: FOX One + ESPN Bundle

Learn more about the San Francisco 49ers vs. the Indianapolis Colts on FOX Sports!

49ers vs. Colts: Head-to-Head

Indianapolis has defeated San Francisco two times in the past two matchups.
Indianapolis has tallied 56 points in the last two matchups while only giving up 41 to San Francisco

49ers' 2025 Schedule

Date	Opponent	Score	TV
9/7/2025	at Seahawks	W 17-13	FOX
9/14/2025	at Saints	W 26-21	FOX
9/21/2025	Cardinals	W 16-15	FOX
9/28/2025	Jaguars	L 26-21	FOX
10/2/2025	at Rams	W 26-23	Amazon Prime Video
10/12/2025	at Buccaneers	L 30-19	CBS
10/19/2025	Falcons	W 20-10	NBC
10/26/2025	at Texans	L 26-15	FOX
11/2/2025	at Giants	W 34-24	CBS
11/9/2025	Rams	L 42-26	FOX
11/16/2025	at Cardinals	W 41-22	FOX
11/24/2025	Panthers	W 20-9	ESPN
11/30/2025	at Browns	W 26-8	CBS
12/14/2025	Titans	W 37-24	FOX
12/22/2025	at Colts	-	ESPN
12/28/2025	Bears	-	NBC/Peacock
TBD	Seahawks	-	-

49ers Stats & Insights

San Francisco ranks 23rd in pass defense this year (227.6 passing yards allowed per game), but has been thriving on the offensive side of the ball, ranking fifth-best in the NFL with 246.1 passing yards per game.
On offense, the 49ers rank 26th in the NFL with 101.4 rushing yards per game. Meanwhile, they rank 12th in rushing yards allowed per contest (106.1).
San Francisco has forced 14 total turnovers (23rd in NFL) this season and have turned it over 19 times (20th in NFL) for a turnover margin of -5, 24th-ranked in the league.

49ers Key Players

McCaffrey has been helping the offense in the running game, rushing for 922 yards and nine touchdowns in 14 games.
Mac Jones has hit the gridiron for 10 games in 2025, and he's delivered 2,151 passing yards, 13 touchdowns, six interceptions and a 69.6% completion percentage.
Brock Purdy has been a key part of the 49ers' offense this season, registering 1,442 passing yards with 12 passing touchdowns, seven interceptions and a 67.9% completion percentage.

Colts' 2025 Schedule

Date	Opponent	Score	TV
9/7/2025	Dolphins	W 33-8	CBS
9/14/2025	Broncos	W 29-28	CBS
9/21/2025	at Titans	W 41-20	CBS
9/28/2025	at Rams	L 27-20	FOX
10/5/2025	Raiders	W 40-6	FOX
10/12/2025	Cardinals	W 31-27	FOX
10/19/2025	at Chargers	W 38-24	CBS
10/26/2025	Titans	W 38-14	CBS
11/2/2025	at Steelers	L 27-20	CBS
11/9/2025	vs. Falcons	W 31-25	NFL Network
11/23/2025	at Chiefs	L 23-20	CBS
11/30/2025	Texans	L 20-16	CBS
12/7/2025	at Jaguars	L 36-19	CBS
12/14/2025	at Seahawks	L 18-16	CBS
12/22/2025	49ers	-	ESPN
12/28/2025	Jaguars	-	FOX
TBD	at Texans	-	-

Colts Stats & Insights

Indianapolis' defense has been bottom-five in pass defense this season, surrendering 247.6 passing yards per game, which ranks third-worst in the NFL. Offensively, it ranks 11th with 229 passing yards per contest.
The Colts have been top-five in rushing on both sides of the ball this season, as they rank fifth-best in rushing yards per game (128.9) and fourth-best in rushing yards allowed per game (95.1).
With 18 forced turnovers (12th in NFL) and 16 turnovers committed (10th in NFL) this season, Indianapolis ranks 10th in the NFL with a turnover margin of +2.

Colts Key Players

In 14 games, Taylor has run for 1,443 yards (103.1 per game) and 16 touchdowns.
In 14 games, Michael Pittman Jr. has 72 catches for 725 yards (51.8 per game) and seven touchdowns.
In the passing game, Tyler Warren has scored four TDs, catching 63 balls for 718 yards (51.3 per game).

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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