How to Watch 49ers vs. Panthers: Time, TV Channel and Live Stream – 2025 Week 12

Christian McCaffrey and the San Francisco 49ers (7-4) meet the Carolina Panthers (6-5) on Monday at 8:15 p.m. ET at Levi's Stadium.

The 49ers are putting up 349.4 yards per game on offense this season (10th in NFL), and they are giving up 352.9 yards per game (26th) on defense. The Panthers have been sputtering on offense, ranking fifth-worst in the NFL with 18.8 points per game. They have been more effective on defense, allowing 22.6 points per contest (13th-ranked).

We dive into all of the info you need before this contest starts below, including how to watch on TV.

Check out the full NFL schedule on FOX Sports! Or visit FOX Sports' NFL hub for everything you need to make the most of this season’s action.

How to Watch 49ers vs. Panthers

• When: Monday, November 24, 2025 at 8:15 p.m. ET
• Where: Levi's Stadium in Santa Clara, California
• TV: ESPN
• Live Box Score: Fox Sports

Learn more about the San Francisco 49ers vs. the Carolina Panthers on FOX Sports!

49ers vs. Panthers: Head-to-Head

• San Francisco has won against Carolina two times in the past three matchups.
• Carolina has scored 40 fewer points than San Francisco in their past three games.

49ers' 2025 Schedule

49ers Stats & Insights

• San Francisco has struggled defensively against the pass, ranking fifth-worst in the NFL (249.1 passing yards allowed per game) this season. However, the 49ers rank third-best on the offensive side of the ball, putting up 254.5 passing yards per game.
• The 49ers have been a bottom-five run offense this year, ranking fifth-worst with 94.8 rushing yards per game. On defense, they are ranked 14th in the NFL (103.8 rushing yards allowed per game).
• San Francisco has the 25th-ranked turnover margin in the league at -5, forcing 10 turnovers (23rd in NFL) while turning it over 15 times (24th in NFL).

49ers Key Players

• The 49ers' offense has been carried by McCaffrey, who has run for 707 yards (64.3 yards per carry) and six rushing touchdowns.
• In nine games, Mac Jones has passed for 2,151 yards (239 yards per game) to go along with 13 touchdowns, six interceptions, and a completion percentage of 69.6%.
• As part of the 49ers' aerial attack, Jauan Jennings has caught 32 balls on 56 targets for 378 yards and three touchdowns.

Panthers' 2025 Schedule

Panthers Stats & Insights

• From an offensive standpoint, Carolina is putting up 187.2 passing yards per contest (27th-ranked). It ranks 16th in the NFL on the other side of the ball (212.8 passing yards allowed per game).
• With 127.1 rushing yards per game on offense, the Panthers rank ninth in the NFL. Defensively they rank 16th, allowing 113.1 rushing yards per contest.
• Carolina has recorded 11 forced turnovers (21st in NFL) and committed 15 turnovers (24th in NFL) this season for a -4 turnover margin that ranks 21st in the NFL.

Panthers Key Players

• Rico Dowdle has rushed for 833 yards (75.7 per game) and five touchdowns in 11 games.
• Bryce Young has passed for 1,962 yards (196.2 per game), completing 62.7% of his throws, with 14 touchdowns and seven interceptions in 10 games.
• In the passing game, Tetairoa McMillan has scored four TDs, catching 54 balls for 748 yards (68 per game).

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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