Chiefs vs. Chargers 2025 Prediction, Odds, Picks - Dec 14

The Kansas City Chiefs (6-7) and Los Angeles Chargers (9-4) will play each other in a battle of two division rivals. The Chiefs are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The expected point total for the matchup is set at 41.5.

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Chiefs vs. Chargers Odds & Betting Lines

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Chiefs vs. Chargers Prediction & Pick

• Pick ATS: Chiefs (-4.5)
  
• Pick OU: Over (41.5)
  
• Prediction: Chiefs 24 - Chargers 19

How to Watch Kansas City vs. Los Angeles

• Game date: Sunday, December 14, 2025
• Time: 1 p.m. ET
• Venue: GEHA Field at Arrowhead Stadium
• Location: Kansas City, Missouri
• TV: CBS
• Live Boxscore: FOX Sports

Chiefs vs. Chargers Recent Matchups

• Kansas City has a 4-1 record against Los Angeles in their last five matchups.
• In their last five head-to-head matchups, Kansas City has tallied 101 points against Los Angeles, while surrendering only 83 points.

Kansas City Betting Info

• Kansas City has played 13 games, posting five wins against the spread.
• The Chiefs have been favored by 4.5 points or more three times this season, and covered the spread in three of those matchups.
• Kansas City games this year have gone over the total in four out of 13 opportunities (30.8%).
• When playing as moneyline favorites, the Chiefs are 5-6, picking up a win 45.5% of the time.
• The Chiefs have a 72.6% chance to win this game, based on the implied probability of the moneyline.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes has 3,398 passing yards (third in the NFL), 22 touchdowns (fifth in the NFL) and 10 interceptions this year. He has completed 63.1% of his passes, averaging 261.4 yards per game and 7.2 per attempt.
• He has added 407 rushing yards (31.3 per game) and four touchdowns on the ground.
• Kareem Hunt averages 3.8 yards per carry (35th in the NFL) and 41.9 yards per game, and has 545 total rushing yards. He has scored eight rushing TDs this season.
• He has also hauled in 14 passes (on 19 targets) for 114 receiving yards with one touchdown. He's averaging 8.8 receiving yards and 1.1 catches per game.
• Travis Kelce has five touchdown catches this season, and has 60 catches for 727 yards on 83 targets, while averaging 4.6 catches and 55.9 yards per game.
• Rashee Rice has 46 receptions for 520 yards and five touchdowns. He's been targeted 67 times in the passing game, and averages 6.6 receptions and 74.3 yards in seven games played.

Defense

• Over on defense, Nick Bolton has 112 tackles and seven TFL in 2025. His tackle total leads the Chiefs and is eighth in the NFL.
• Chamarri Conner has one sack in addition to his two TFL and 84 tackles.
• This season, George Karlaftis III has put up six sacks (first on the Chiefs) to go with nine TFL and 41 tackles.
• This season, Trent McDuffie has 63 tackles, two TFL, one sack, and one interception.

Los Angeles Betting Info

• Los Angeles has covered the spread seven times this year (7-6-0).
• Games involving Los Angeles have hit the over on six occasions this season.
• The Chargers have won both games they've played as underdogs this season.
• The implied probability of a win by the Chargers based on the moneyline is 31.7%.

Chargers Stats

Los Angeles' Key Players

Offense

• Through 13 games played this year, Justin Herbert has racked up 2,981 passing yards, with 22 touchdowns (fifth in the NFL) against 11 interceptions and completing 65.6% of his attempts.
• On the ground, Herbert has added one rushing touchdown and 419 rushing yards (second on the Chargers).
• Ladd McConkey has 695 receiving yards and five touchdowns on 59 receptions, while being targeted 95 times.
• Kimani Vidal has rushed for three touchdowns this year, and has totaled 587 rushing yards (58.7 per game and 4.3 per carry).
• Vidal's statistic output includes 14 receptions (1.4 per game) on 20 targets for 123 yards (12.3 per game) and one receiving touchdown.
• Quentin Johnston has been targeted 72 times, resulting in 42 catches for 533 yards (seventh in the NFL).

Defense

• Tuli Tuipulotu has put up 10 sacks (first on the Chargers and ninth in the NFL) to go with 16 TFL and 35 tackles over 12 games in 2025.
• Daiyan Henley has 3.5 sacks (fifth on the Chargers) to go with five TFL, 80 tackles, and one interception.
• Derwin James has 70 tackles, six TFL, two sacks, and one interception in the 2025 season. He is second on the Chargers in tackles.
• Khalil Mack has 23 tackles, five TFL, and 4.5 sacks.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Kansas City Chiefs

Los Angeles Chargers