Chiefs vs. Chargers 2025 Prediction, Odds, Picks - Dec 14

The Kansas City Chiefs (6-7) are the favorites -- expected to win by at least a field goal, but less than a touchdown (currently -5.5) -- versus the Los Angeles Chargers (9-4) in a battle of two division rivals. The predicted point total for the matchup is 41.5.

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Chiefs vs. Chargers Odds & Betting Lines

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Chiefs vs. Chargers Prediction & Pick

• Pick ATS: Chargers (+5.5)
  
• Pick OU: Over (41.5)
  
• Prediction: Chiefs 24 - Chargers 19

How to Watch Kansas City vs. Los Angeles

• Game date: Sunday, December 14, 2025
• Time: 1 p.m. ET
• Venue: GEHA Field at Arrowhead Stadium
• Location: Kansas City, Missouri
• TV: CBS
• Live Boxscore: FOX Sports

Chiefs vs. Chargers Recent Matchups

• In their last five head-to-head contests, Kansas City has won against Los Angeles four times.
• Over their last five head-to-head matchups, Kansas City has scored 101 points, while Los Angeles has posted 83.

Kansas City Betting Info

• In 13 Kansas City games this season, it has five wins against the spread.
• The Chiefs have covered the spread three times this season (3-0 ATS) when playing as at least 5.5-point favorites.
• Kansas City has combined with its opponent to gone over the point total in 30.8% of its contests this year (four times in 13 games with a set point total).
• The Chiefs have a 5-6 record in games they played as the moneyline favorite (winning 45.5% of those games).
• The Chiefs have a 72.6% chance to win this game, based on the implied probability of the moneyline.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes ranks third in the NFL with 3,398 passing yards through 13 games this year, averaging 261.4 per game with a 63.1% completion percentage and 22 touchdowns (fifth in the NFL) against 10 interceptions.
• He has also rushed for 407 yards (second on the Chiefs) and added four touchdowns on the ground, while averaging 31.3 rushing yards per game.
• Kareem Hunt has racked up 545 rushing yards with eight touchdowns (41.9 yards per game over 13 games). His 3.8 yards per attempt rank 35th in the NFL.
• He has also caught 14 passes (on 19 targets) for 114 receiving yards with one touchdown. He's averaging 8.8 receiving yards and 1.1 catches per game.
• Travis Kelce has five touchdown catches this season, and has 60 catches for 727 yards on 83 targets, while averaging 4.6 catches and 55.9 yards per game.
• Rashee Rice has 46 receptions for 520 yards and five touchdowns. He's been targeted 67 times in the passing game, and averages 6.6 receptions and 74.3 yards through seven games played.

Defense

• On defense, Nick Bolton has 112 tackles and seven TFL in 2025. His tackle total leads the Chiefs and is eighth in the NFL.
• Chamarri Conner has 84 tackles, two TFL, and one sack this season. He's second on the Chiefs in tackles.
• This season, George Karlaftis III has recorded six sacks (first on the Chiefs) to go along with his nine TFL and 41 tackles.
• This season, Trent McDuffie has 63 tackles, two TFL, one sack, and one interception. He's fourth on the Chiefs in tackles.

Los Angeles Betting Info

• Los Angeles has covered the spread seven times over 13 games with a set total.
• Los Angeles games have gone over the total six times this year.
• The Chargers have won both games they've played as underdogs this season.
• The Chargers have a 31.7% chance to win this game based on the implied probability of the moneyline.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has thrown for 2,981 yards this year, with 22 touchdowns (fifth in the NFL) and 11 interceptions. He is completing 65.6% of his passes while averaging 229.3 yards per game and 7.1 per attempt.
• Herbert has also rushed for one touchdown and 419 yards (second on the Chargers).
• Ladd McConkey has 59 catches for 695 yards and five receiving touchdowns. He has been targeted 95 times and averages 4.5 receptions per game in 13 games played.
• Kimani Vidal is averaging 58.7 rushing yards per game this season (587 total yards), while scoring three rushing touchdowns.
• Vidal has helped out in the passing attack, picking up 123 receiving yards (12.3 per game) on 14 catches (1.4 per game), while being targeted 20 times. He has one receiving touchdown.
• Quentin Johnston has been targeted 72 times, resulting in 42 catches for 533 yards (seventh in the NFL).

Defense

• Tuli Tuipulotu has 35 tackles, 16 TFL, 10 sacks, and three passes defended in 2025.
• Daiyan Henley has one interception on top of 80 tackles, five TFL, 3.5 sacks, and four passes defended.
• Derwin James has recorded two sacks as well as six TFL, 70 tackles, and one interception in the 2025 season.
• Khalil Mack has registered 4.5 sacks (third on the Chargers) to go with five TFL and 23 tackles through nine games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Kansas City Chiefs

Los Angeles Chargers