Chargers vs. Giants 2025 Prediction, Odds, Picks - Sep 28

The Los Angeles Chargers (3-0) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6) over the New York Giants (0-3). The Chargers have won three games straight. The expected point total for the matchup is set at 43.5.

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Chargers vs. Giants Odds & Betting Lines

Chargers vs. Giants Prediction & Pick

• Pick ATS: Chargers (-6)
  
• Pick OU: Under (43.5)
  
• Prediction: Chargers 27 - Giants 14

How to Watch Los Angeles vs. New York

• Game date: Sunday, September 28, 2025
• Time: 1 p.m. ET
• Venue: MetLife Stadium
• Location: East Rutherford, New Jersey
• TV: CBS
• Live Boxscore: FOX Sports

Chargers vs. Giants Recent Matchups

• In their past two head-to-head matchups, Los Angeles has beaten New York two times.
• New York has been outpaced by 21 points in its last two tilts against Los Angeles.

Los Angeles Betting Info

• Against the spread, Los Angeles is 3-0-0 this season.
• Los Angeles games this year have hit the over on one of three set point totals (33.3%).
• The Chargers have been moneyline favorites in two other matchups this season, and they won both.
• The Chargers have an implied win probability, based on the moneyline, of 74.0%.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has 860 passing yards (second in the NFL), six touchdowns (fifth in the NFL) and one interception this year. He has completed 66.7% of his passes, averaging 286.7 yards per game and 8.0 per attempt.
• He has added 69 rushing yards (23.0 per game) without a touchdown on the ground.
• Quentin Johnston has 14 catches for 239 yards (sixth in the NFL) and three TDs. In three games, he is averaging 4.7 catches and 79.7 yards per game.
• In the passing game, Keenan Allen, has contributed with 194 receiving yards and three touchdowns (fourth in the NFL) after catching 19 balls (10th in the NFL) on 28 targets. Per game, he's averaging 64.7 yards and 6.3 receptions in three games.
• Omarion Hampton has rushed for 142 yards with one touchdown (47.3 yards per game in three games).
• He's added nine catches (on 11 targets) for 73 receiving yards with zero touchdowns. He's averaging 24.3 receiving yards and 3.0 receptions per game.

Defense

• Over on the defensive side, Derwin James has 26 tackles, 5.0 TFL, and one sack in 2025.
• Daiyan Henley has 2.0 sacks (first on the Chargers) in addition to his 3.0 TFL, 22 tackles, and one interception.
• Tarheeb Still has recorded 15 tackles and 1.0 TFL this year.
• This season, Tony Jefferson has nine tackles and one interception.

New York Betting Info

• New York has covered the spread one time over three games with a set spread.
• This season, the Giants are winless against the spread when entering a game as an underdog of 6 points or more.
• This year, New York games have hit the over just once.
• The Giants have been the underdog in three games this season, and they have failed to win any of those contests.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 30.3% chance to win.

Giants Stats

New York's Key Players

Offense

• In three games played this year, Russell Wilson has amassed 778 passing yards (seventh-best in the NFL), with three touchdowns against three interceptions and completing 59.1% of his passes.
• On the ground, Wilson has added 94 rushing yards (second on the Giants).
• Malik Nabers has 251 receiving yards (fourth in the NFL) and two touchdowns (seventh in the NFL) on 16 receptions, while being targeted 32 times.
• Cam Skattebo is averaging 34.0 rushing yards per game this season (102 total yards), while scoring two rushing touchdowns.
• Skattebo's statistic output includes 10 receptions (3.3 per game) on 13 targets for 87 yards (29.0 per game), but he has not found the end zone through the air.
• Wan'Dale Robinson has been targeted 22 times, resulting in 15 catches for 223 yards .

Defense

• So far in 2025, Brian Burns has 15 tackles, 5.0 TFL, and four sacks through three games.
• Paulson Adebo has 27 tackles and three passes defended.
• Andru Phillips has 20 tackles, 2.0 TFL, and one interception in the 2025 campaign. He is third on the Giants in tackles.
• Bobby Okereke has totaled 34 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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New York Giants

Los Angeles Chargers