Chargers vs. Colts 2025 Prediction, Odds, Picks - Oct 19

The Los Angeles Chargers (4-2) are considered favorites (-1.5) according to the point spread ahead of their game against the Indianapolis Colts (5-1) on October 19, 2025, starting at 4:05 p.m. ET, airing on CBS. An over/under of 48.5 points has been established for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

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Matt Hasselbeck joins Colin Cowherd to react to Tua Tagovailoa calling out his teammates after a 1-5 start and break down why the Kansas City Chiefs remain a dangerous team despite their slow start. Hasselbeck also breaks down how Sam Darnold and Jaxon Smith-Njigba have chemistry six weeks into the season and Drake Maye is leading the New England Patriots to their best start since 2019. He also reacts to Justin Herbert leading the game-winning drive against the Miami Dolphins, along with Aaron Rodgers leading the Pittsburgh Steelers to a 4-1 start.

Chargers vs. Colts Odds & Betting Lines

Chargers vs. Colts Prediction & Pick

• Pick ATS: Colts (+1.5)
  
• Pick OU: Under (48.5)
  
• Prediction: Colts 27 - Chargers 20

How to Watch Los Angeles vs. Indianapolis

• Game date: Sunday, October 19, 2025
• Time: 4:05 p.m. ET
• Venue: SoFi Stadium
• Location: Inglewood, California
• TV: CBS
• Live Boxscore: FOX Sports

Chargers vs. Colts Recent Matchups

• In their last two head-to-head meetings, Los Angeles has beaten Indianapolis two times.
• Over their last two head-to-head matchups, Los Angeles has put up 50 points, while Indianapolis has compiled 27.

Los Angeles Betting Info

• Against the spread, Los Angeles is 3-3-0 this season.
• The Chargers have covered the spread twice when favored by 1.5 points or more this season (in five opportunities).
• Los Angeles games this year have hit the over on two of six set point totals (33.3%).
• When playing as the moneyline favorite, the Chargers are 3-2 (winning 60% of the time).
• The implied probability in this matchup, considering the moneyline, gives the Chargers a 56.5% chance to win.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has 1,493 passing yards (eighth in the NFL), 10 touchdowns (10th in the NFL) and four interceptions this year. He has completed 67.6% of his attempts, averaging 248.8 yards per game and 6.9 per attempt.
• In addition to his passing stats, Herbert has 155 rushing yards (second on the Chargers), but no touchdowns.
• Quentin Johnston has caught 26 passes on 41 targets for 377 total yards and four touchdowns. He is averaging 5.2 catches and 75.4 yards per game through five games.
• In the passing attack, Keenan Allen, has totaled 316 receiving yards and three touchdowns after pulling down 33 balls on 51 targets. Per game, he's averaging 52.7 yards and 5.5 receptions in six games.
• Ladd McConkey averages 4.7 receptions and 52.2 yards per game, and has 313 total receiving yards and 28 catches. He's gotten 43 total targets, and has caught two touchdown passes.

Defense

• On the defensive side, Derwin James has one interception to go with 42 tackles, five TFL, 1.5 sacks, and three passes defended in 2025.
• Daiyan Henley has intercepted one pass and added 46 tackles, three TFL, two sacks, and two passes defended.
• Tuli Tuipulotu has recorded 18 tackles, seven TFL, and five sacks this year.
• This season, Troy Dye has 38 tackles, four TFL, and one sack. He's third on the Chargers in tackles.

Indianapolis Betting Info

• Indianapolis has covered the spread four times in six games with a set total.
• The Colts have covered the spread once this year when underdogs by 1.5 points or more (in two chances).
• Games involving Indianapolis have hit the over on three occasions this season.
• The Colts have split the two games they've played as underdogs this season.
• The Colts have a 47.6% chance to win this game based on the implied probability of the moneyline.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has rushed for seven touchdowns this year, and has accumulated 603 total rushing yards (100.5 per game and 5.2 per carry).
• On top of his impact in the run game, Taylor has caught 20 passes (on 22 targets) for 147 yards (fifth on the Colts), with one receiving touchdown. He's averaging 24.5 yards per game.
• In six games, Daniel Jones has 1,502 passing yards (seventh-best in the NFL), with eight touchdowns against three interceptions and completing 71.7% of his passes.
• Jones also has four rushing touchdowns and 76 rushing yards (second on the Colts).
• In six games played this season, Tyler Warren has 29 catches (4.8 receptions per game on 6.7 targets per game) for 370 yards and two receiving touchdowns.
• Michael Pittman Jr. has 28 catches for 293 yards and four receiving touchdowns (seventh in the NFL). He averages 4.7 yards per game through six games and has been targeted 38 times.

Defense

• Nick Cross has 47 tackles, four TFL, 1.5 sacks, and two passes defended in 2025.
• DeForest Buckner has 31 tackles, five TFL, and one sack. He is fourth on the Colts in tackles.
• Zaire Franklin has 37 tackles, one TFL, one sack, and three passes defended in the 2025 season.
• Mekhi Blackmon has one sack (fifth on the Colts) to go with 28 tackles and two interceptions over six games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Chargers

Indianapolis Colts