Broncos vs. Colts 2025 Prediction, Odds, Picks - Sep 14

The Denver Broncos (1-0) are considered favorites (-1.5) according to the bookmakers ahead of their game versus the Indianapolis Colts (1-0) on September 14, 2025, starting at 4:05 p.m. ET, airing on CBS. The predicted point total for the game is 43.5.

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Broncos vs. Colts Odds & Betting Lines

Broncos vs. Colts Prediction & Pick

• Pick ATS: Broncos (-1.5)
  
• Pick OU: Over (43.5)
  
• Prediction: Broncos 27 - Colts 18

How to Watch Denver vs. Indianapolis

• Game date: Sunday, September 14, 2025
• Time: 4:05 p.m. ET
• Venue: Lucas Oil Stadium
• Location: Indianapolis, Indiana
• TV: CBS
• Live Boxscore: FOX Sports

Broncos vs. Colts Recent Matchups

• Denver and Indianapolis have been evenly matched over their last four meetings, sharing the same 2-2 record.
• In their last four head-to-head matchups, Denver has racked up 78 points against Indianapolis, while allowing only 53 points.

Denver Betting Info

• Denver compiled a 12-5-0 record against the spread last season.
• Against the spread, as 1.5-point favorites or greater, the Broncos went 8-0 last season.
• A total of 10 Denver games last season went over the point total.
• The Broncos won all eight of the games they were listed as the moneyline favorite last season.
• Denver won all eight games it played as a moneyline favorite with odds of -130 or shorter.
• The Broncos have a 56.5% chance to win this contest based on the moneyline's implied probability.

Broncos Stats (2024)

Denver's Key Players

Offense

• Bo Nix passed for 3,775 yards last year, with 29 touchdowns (sixth in the NFL) and 12 interceptions. He completed 66.3% of his passes while averaging 222.1 yards per game and 6.7 per attempt.
• On the ground, Nix added four rushing touchdowns and 430 rushing yards.
• J.K. Dobbins averaged 69.6 rushing yards per contest through 13 games for the Chargers (905 total yards), while scoring nine rushing touchdowns.
• Dobbins also had 32 catches for 153 yards. He was targeted 38 times and averaged 11.8 yards per game.
• Last year, Courtland Sutton caught 81 passes for 1,081 receiving yards with eight touchdowns through the air. He was targeted 135 total times and averaged 5.1 receptions per game over 16 games played.
• Marvin Mims was targeted 52 times, resulting in 39 catches for 503 yards.

Defense

• Nik Bonitto intercepted one pass to go with 48 tackles, 16.0 TFL, 13.5 sacks, and four passes defended in 2024.
• Brandon Jones had 2.0 TFL, 115 tackles, and three interceptions.
• Zach Allen recorded 8.5 sacks as well as 15.0 TFL and 61 tackles in the 2024 season.
• Jonathon Cooper amassed 58 tackles, 11.0 TFL, 10.5 sacks, and one pass defended.

Indianapolis Betting Info

• Indianapolis won nine games against the spread last year, failing to cover eight times.
• The Colts had an ATS record of 6-4 as underdogs of 1.5 points or more last season.
• Last season, nine Indianapolis games hit the over.
• The Colts were underdogs 10 times last season and won three of those games.
• Indianapolis had a record of 3-7, a 30% win rate, when it was set as an underdog of +110 or more by oddsmakers last season.
• The implied probability of a win by the Colts, based on the moneyline, is 47.6%.

Colts Stats (2024)

Indianapolis' Key Players

Offense

• Last season in 14 games, Jonathan Taylor churned out 1,431 yards rushing (fourth in NFL) and scored 11 rushing TDs. He averaged 102.2 yards per game and 4.7 per carry (11th in NFL).
• Taylor's offensive contributions included 18 catches (1.3 per game) on 31 targets for 136 yards (9.7 per game). He had one receiving TD.
• Anthony Richardson had 1,814 passing yards, eight TD passes and 12 INTs. His completion percentage was 47.7% and he averaged 164.9 yards per game and 6.9 per attempt.
• Richardson also had six rushing TDs and 499 rushing yards.
• For the Giants last year, Daniel Jones passed for 2,070 yards, eight TDs and had seven INTs. He completed 63.3% of his passes, averaging 207.0 yards per game and 6.1 per attempt.
• Daniel Jones also ran for two TDs and 265 yards.
• Alec Pierce had 824 yards receiving and seven TDs via 37 catches on 69 targets.

Defense

• Zaire Franklin intercepted two balls in addition to 173 tackles, 11.0 TFL, 3.5 sacks, and six passes defended in 2024.
• Nick Cross had 1.0 sack to go along with his 6.0 TFL, 145 tackles, and three interceptions over 17 games.
• Camryn Bynum had 2.0 TFL, 96 tackles, and three interceptions during the 2024 season for the Vikings.
• Kenny Moore II totaled 0.5 sacks plus 4.0 TFL, 78 tackles, and three interceptions over 15 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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