Bills vs. Eagles 2025 Prediction, Odds, Picks - Dec 28

The Buffalo Bills (11-4) will be attempting to continue a four-game winning run against the Philadelphia Eagles (10-5). The Bills are small favorites (-1.5). The game has an over/under of 44.5 points.

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Bills vs. Eagles Odds & Betting Lines

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Bills vs. Eagles Prediction & Pick

• Pick ATS: Bills (-1.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Bills 26 - Eagles 22

How to Watch Buffalo vs. Philadelphia

• Game date: Sunday, December 28, 2025
• Time: 4:25 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Bills vs. Eagles Recent Matchups

• Over their last two meetings, Philadelphia has tallied two wins versus Buffalo.
• In their last two head-to-head matchups, Philadelphia has racked up 68 points versus Buffalo, while allowing only 47 points.

Buffalo Betting Info

• Against the spread, Buffalo is 7-8-0 this season.
• When playing as at least 1.5-point favorites this season, the Bills have an ATS record of 5-8.
• Buffalo games this year have hit the over on eight of 15 set point totals (53.3%).
• The Bills have won 69.2% of the time they have played as the moneyline favorite (9-4).
• The Bills have a 54.1% chance to win this matchup, based on the implied probability of the moneyline.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 3,406 passing yards (10th in the NFL), 25 touchdowns (fifth in the NFL) and 10 interceptions this year. He has completed 69.6% of his passes, averaging 227.1 yards per game and 8 per attempt.
• He has also rushed for 552 yards (second on the Bills) and added 12 touchdowns on the ground, while averaging 36.8 rushing yards per game.
• James Cook has recorded 1,532 rushing yards (first in the NFL) with 12 touchdowns (102.1 yards per game across 15 games). His 5.3 yards per attempt rank second in the NFL.
• Cook's 36 targets through the air have turned into 32 catches (2.1 per game) for 288 yards (19.2 per game) and two touchdowns.
• Through 15 games played, Khalil Shakir is averaging 45.6 yards and 4.4 receptions per game to total 684 receiving yards and 66 catches. He's been targeted 88 times, and has four receiving touchdowns.
• Dalton Kincaid has 36 catches for 523 yards and five touchdowns. He's been targeted 46 times in the passing game, and averages 3.3 receptions and 47.5 yards through 11 games played.

Defense

• On the defensive side, Cole Bishop has 83 tackles, four TFL, two sacks, and three interceptions in 2025. His tackle total leads the Bills.
• Greg Rousseau has 6.5 sacks (first on the Bills) to go with six TFL and 43 tackles.
• Joey Bosa has put up 27 tackles, eight TFL, five sacks, and two passes defended.
• So far this season, Terrel Bernard has 62 tackles, seven TFL, and one interception. He's third on the Bills in tackles.

Philadelphia Betting Info

• Philadelphia is 9-6-0 against the spread this season.
• The Eagles have been underdogs by 1.5 points or more once this year and covered the spread.
• Philadelphia's games have finished with a final combined score above the over/under six times this year.
• The Eagles won the only game they've played as the underdog this season.
• The oddsmakers' moneyline implies a 50.5% chance of a victory for the Eagles.

Eagles Stats

Philadelphia's Key Players

Offense

• In 15 games played this year, Jalen Hurts has amassed 3,114 passing yards, with 24 touchdowns (ninth in the NFL) against six interceptions and completing 65.8% of his passes.
• Hurts has also rushed for eight touchdowns and 416 yards (second on the Eagles).
• Saquon Barkley averages 71.5 rushing yards per game over 15 games (1,072 total yards to rank ninth in the NFL), while scoring seven rushing touchdowns.
• Barkley has also picked up 273 receiving yards (18.2 per game) on 37 catches (2.5 per game). He's been targeted 50 times and has caught two touchdown passes.
• A.J. Brown has recorded 935 receiving yards and seven touchdowns on 73 receptions, while being targeted 114 times on the season.
• Dallas Goedert has been targeted 76 times, resulting in 57 catches for 583 yards (third in the NFL).

Defense

• In 2025, Zack Baun has 3.5 sacks to go with six TFL, 117 tackles, and two interceptions through 15 games.
• Cooper DeJean has two interceptions on top of 76 tackles, four TFL, and 16 passes defended.
• Jalyx Hunt has recorded 4.5 sacks (second on the Eagles) as well as seven TFL, 43 tackles, and two interceptions in the 2025 campaign.
• Jordan Davis' season stats include 65 tackles, nine TFL, and 4.5 sacks in 15 games. He is fourth on the Eagles in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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