Bills vs. 49ers 2024 Prediction, Odds, Picks - Dec 1

Updated Dec. 1, 2024 4:43 p.m. ET

Data Skrive

The Buffalo Bills (9-2) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6.5) over the San Francisco 49ers (5-6). The Bills have won six games in a row. The game has an over/under of 45 points.

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Bills vs. 49ers Odds & Betting Lines

Bills vs 49ers Betting Information updated as of December 1, 2024, 11:33 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-6.5	-110	-110	45	-110	-120

Bills vs. 49ers Prediction & Pick

Pick ATS: Bills (-6.5)
Pick OU: Over (45)
Prediction: Bills 31 - 49ers 17

How to Watch Buffalo vs. San Francisco

Game Date: Sunday, December 1, 2024
Time: 8:20 p.m. ET
Venue: Highmark Stadium
Location: Orchard Park, New York
TV: NBC
Live Boxscore: FOX Sports

Bills vs. 49ers Recent Matchups

Over their last five meetings, San Francisco has three wins against Buffalo.
In their last five head-to-head matchups, San Francisco has scored 113 points against Buffalo, while surrendering only 92 points.

Buffalo Betting Info

In 11 Buffalo games this year, it has seven wins against the spread.
The Bills have covered the spread once when favored by 6.5 points or more this season (in three opportunities).
Buffalo games in 2024 have hit the over seven times in 11 opportunities (63.6%).
The Bills have won each of the eight games they were favored on the moneyline this season.
The Bills have a 73.5% chance to win this matchup, based on the implied probability of the moneyline.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	226.1 (2,487)	14
Rush yards	119.2 (1,311)	11
Points scored	29.1 (320)	4
Pass yards against	210.0 (2,310)	12
Rush yards against	119.1 (1,310)	14
Points allowed	19.5 (214)	7

Buffalo's Key Players

Offense

Josh Allen has 2,543 passing yards in 11 games this year, averaging 231.2 per game with a 64% completion percentage and 18 touchdowns (eighth in the NFL) against five interceptions.
In addition to his passing statistics, Allen also has 316 rushing yards (second on the Bills), with five rushing touchdowns.
James Cook has racked up 596 rushing yards with 10 touchdowns (59.6 yards per game over 10 games). His 4.4 yards per attempt rank 17th in the league.
Cook's 31 targets through the air have resulted in 25 catches (2.5 per game) for 182 yards (18.2 per game) and one touchdown.
In 10 games played, Khalil Shakir is averaging 59.9 yards and 5.6 receptions per game to total 599 receiving yards and 56 catches. He's been targeted 66 times, and has two receiving touchdowns.
Keon Coleman has 22 receptions for 417 yards and three touchdowns. He's been targeted 36 times in the air attack, and averages 2.4 receptions and 46.3 yards in nine games played.

Defense

On defense, Dorian Williams has five TFL and 95 tackles in 2024.
Gregory Rousseau has 37 tackles, 12 TFL, and 5.5 sacks this season.
This season, Damar Hamlin has recorded two TFL, 65 tackles, and two interceptions.
So far this season, Terrel Bernard has 57 tackles, four TFL, one sack, and two interceptions.

San Francisco Betting Info

San Francisco is 4-7-0 against the spread this season.
The 49ers have yet to cover the spread this season when underdogs by 6.5 points or more.
San Francisco's games have finished with a final combined score above the over/under six times this season.
The 49ers lost the only game they've played as the underdog this season.
Sportsbooks have implied with the moneyline set for this matchup that the 49ers have a 30.8% chance to win.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	246.2 (2,708)	4
Rush yards	138.4 (1,522)	7
Points scored	23.6 (260)	14
Pass yards against	193.5 (2,128)	6
Rush yards against	110.8 (1,219)	11
Points allowed	23.6 (260)	20

San Francisco's Key Players

Offense

Brock Purdy has passed for 2,613 yards this year, with 13 touchdowns and eight interceptions. He is completing 66% of his passes while averaging 261.3 yards per game and 8.5 per attempt.
Purdy has also rushed for four touchdowns and 267 yards (second on the 49ers).
George Kittle has 49 catches for 642 yards and eight receiving touchdowns (third in the NFL). He has been targeted 59 times and averages 5.4 receptions per game through nine games played.
Jordan Mason is averaging 64.6 rushing yards per game this season (711 total yards), while scoring three rushing touchdowns.
Jauan Jennings has been targeted 65 times, resulting in 47 catches for 628 yards .

Defense

Fred Warner has recorded one sack to go with three TFL, 84 tackles, and two interceptions through 11 games in 2024.
Nick Bosa has 36 tackles, 10 TFL, seven sacks, and one interception.
Over the 2024 campaign, Deommodore Lenoir has 67 tackles, two TFL, and two interceptions in 11 games.
Leonard Floyd has totaled 6.5 sacks (second on the 49ers) as well as six TFL and 32 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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