2025 NFL Week 10 Predictions, Betting Odds & TV Schedule

The Week 10 NFL lineup has lots in store. Among those games is the Los Angeles Rams squaring off against the San Francisco 49ers.

Take a peek at our betting preview for the NFL's Week 10.

Check out the full NFL schedule on FOX Sports!

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Week 10 Betting Lines & Game Info

Denver Broncos vs. Las Vegas Raiders

Odds & Prediction

• Spread: Broncos (-9)
• Moneyline: Broncos -515, Raiders +384
• Total: 42.5 points
• Prediction: Broncos 31, Raiders 12

How to Watch

• Game Date: Thursday, Nov. 6
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: Denver, Colorado

Indianapolis Colts vs. Atlanta Falcons

Odds & Prediction

• Spread: Colts (-6.5)
• Moneyline: Colts -292, Falcons +236
• Total: 48.5 points
• Prediction: Colts 31, Falcons 15

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 9:30 a.m. ET
• TV Channel: NFL Network
• Box Score
• Location: Berlin, Germany

Chicago Bears vs. New York Giants

Odds & Prediction

• Spread: Bears (-4.5)
• Moneyline: Bears -223, Giants +184
• Total: 45.5 points
• Prediction: Bears 28, Giants 24

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Chicago, Illinois

New York Jets vs. Cleveland Browns

Odds & Prediction

• Spread: Browns (-2.5)
• Moneyline: Browns -130, Jets +110
• Total: 37.5 points
• Prediction: Jets 23, Browns 21

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: East Rutherford, New Jersey

Miami Dolphins vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-8)
• Moneyline: Bills -463, Dolphins +352
• Total: 50 points
• Prediction: Bills 30, Dolphins 19

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Miami Gardens, Florida

Minnesota Vikings vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-4.5)
• Moneyline: Ravens -236, Vikings +193
• Total: 49 points
• Prediction: Vikings 25, Ravens 24

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Minneapolis, Minnesota

Carolina Panthers vs. New Orleans Saints

Odds & Prediction

• Spread: Panthers (-5.5)
• Moneyline: Panthers -248, Saints +202
• Total: 38.5 points
• Prediction: Panthers 25, Saints 17

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Charlotte, North Carolina

Houston Texans vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Texans (-1)
• Moneyline: Texans -111, Jaguars -108
• Total: 37.5 points
• Prediction: Texans 24, Jaguars 16

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Houston, Texas

Tampa Bay Buccaneers vs. New England Patriots

Odds & Prediction

• Spread: Buccaneers (-2.5)
• Moneyline: Buccaneers -151, Patriots +127
• Total: 48.5 points
• Prediction: Buccaneers 26, Patriots 20

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Tampa, Florida

Seattle Seahawks vs. Arizona Cardinals

Odds & Prediction

• Spread: Seahawks (-7)
• Moneyline: Seahawks -333, Cardinals +265
• Total: 44.5 points
• Prediction: Seahawks 31, Cardinals 15

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Seattle, Washington

Washington Commanders vs. Detroit Lions

Odds & Prediction

• Spread: Lions (-7.5)
• Moneyline: Lions -446, Commanders +342
• Total: 49 points
• Prediction: Lions 30, Commanders 21

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 4:25 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Landover, Maryland

San Francisco 49ers vs. Los Angeles Rams

Odds & Prediction

• Spread: Rams (-5.5)
• Moneyline: Rams -259, 49ers +210
• Total: 49.5 points
• Prediction: Rams 23, 49ers 19

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 4:25 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Santa Clara, California

Los Angeles Chargers vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Chargers (-3)
• Moneyline: Chargers -181, Steelers +151
• Total: 45.5 points
• Prediction: Chargers 26, Steelers 22

How to Watch

• Game Date: Sunday, Nov. 9
• Game Time: 8:20 p.m. ET
• TV Channel: NBC/Peacock
• Box Score
• Location: Inglewood, California

Green Bay Packers vs. Philadelphia Eagles

Odds & Prediction

• Spread: Packers (-1.5)
• Moneyline: Packers -110, Eagles -110
• Total: 45 points
• Prediction: Eagles 25, Packers 22

How to Watch

• Game Date: Monday, Nov. 10
• Game Time: 8:15 p.m. ET
• TV Channel: ABC/ESPN
• Box Score
• Location: Green Bay, Wisconsin

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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