Yankees vs. Red Sox Prediction, Odds, Picks - August 22

Alex Bregman and the Boston Red Sox take on Cody Bellinger and the New York Yankees at Yankee Stadium on Friday at 7:05 p.m. ET. The Red Sox are +162 moneyline underdogs in this matchup with the Yankees (-196). New York is a 1.5-run favorite (at +105 odds). The total for the contest is listed at 8.5 runs.

Here's everything you need from a betting perspective on the Yankees-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Roman Anthony on his Brox debut, Red Sox's win over Yankees 🏆 King of Diamond

John Smoltz spoke with Red Sox's Roman Anthony about his performance against the New York Yankees!

Yankees vs. Red Sox Game Information & Odds

• When: Friday, August 22, 2025 at 7:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: MLB Network, Amazon Prime Video, and NESN

Yankees vs. Red Sox Prediction

• Score Prediction: Yankees 5, Red Sox 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Yankees 53%, Red Sox 47%

Yankees vs. Red Sox Betting Insights

• This season, the Yankees have won 59 out of the 106 games, or 55.7%, in which they've been favored.
• New York is 17-10 this season when entering a game favored by -196 or more on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Yankees have a 66.2% chance to win.
• The Red Sox have been underdogs in 48 games this season and have come away with the win 23 times (47.9%) in those contests.
• Boston has a mark of 1-3 in contests where bookmakers favor it by +162 or worse on the moneyline.
• The Red Sox have an implied victory probability of 38.2% according to the moneyline set for this matchup.

Yankees Recent Betting Performance

• The Yankees have a 6-3 record across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Yankees combined with their opponents to go over the total six times.
• The Yankees' record against the spread is 6-4-0 over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge has accumulated a team-high batting average of .329, while pacing the Yankees in home runs (40) and runs batted in (92).
• Including all MLB hitters, Judge is first in batting average, first in on-base percentage, and first in slugging.
• Bellinger has 20 doubles, five triples, 24 home runs and 38 walks while hitting .272.
• Bellinger is 29th in homers and 23rd in RBI in the majors.
• Bellinger has four games in a row with at least one hit. During his last five outings he is batting .318 with two home runs, a walk and six RBIs.
• Trent Grisham is batting .246 with nine doubles, a triple, 23 home runs and 58 walks.
• Ben Rice is batting .243 with 21 doubles, three triples, 20 home runs and 43 walks.
• Rice has recorded at least one hit in three straight games. In his last five games he is batting .389 with a double, a triple, three home runs, five walks and nine RBIs.

Yankees Team Props

Red Sox Recent Betting Performance

• The Red Sox have played as underdogs in four of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Red Sox and their opponents are 6-4-0 in their last 10 games with a total.
• The Red Sox have three wins against the spread in their last 10 chances.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran leads the team in batting average with a high-water mark of .261.
• In all of the majors, Duran ranks 139th in homers and 39th in RBI.
• Trevor Story has capitalized on opportunities as he paces his team with 79 RBI.
• Story is 55th in home runs and 18th in RBI among all major league batters this season.
• Ceddanne Rafaela has 25 doubles, three triples, 14 home runs and 22 walks while hitting .250.
• Bregman is batting .303 with 24 doubles, 16 home runs and 37 walks.

Red Sox Team Props

Roman Anthony on his Brox debut, Red Sox's win over Yankees 🏆 King of Diamond

John Smoltz spoke with Red Sox's Roman Anthony about his performance against the New York Yankees!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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