Reds vs. Marlins Prediction, Odds, Picks - April 21

Updated Apr. 21, 2025 6:00 p.m. ET

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Nick Lodolo starts for the Cincinnati Reds on Monday at loanDepot park against Eric Wagaman and the Miami Marlins. First pitch is at 6:40 p.m. ET for the first game of a three-game series. The Reds are the favorite in this one, at -119, while the underdog Marlins have -101 odds to play spoiler. Cincinnati is the run-line favorite (-1.5). The over/under for the contest has been set at 8 runs.

Here is everything you need to know from a betting perspective on the Reds-Marlins game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

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Check out the best moments between the Miami Marlins and the Philadelphia Phillies.

Reds vs. Marlins Game Information & Odds

• When: Monday, April 21, 2025 at 6:40 p.m. ET
• Where: loanDepot park in Miami, Florida
• How to watch on TV: FDSFL and FDSOH

Reds vs. Marlins Prediction

• Score Prediction: Reds 5, Marlins 4
• Total Prediction: Over 8 runs
• Win Probabilities: Reds 54%, Marlins 46%

Reds vs. Marlins Betting Insights

• The Reds have entered the game as favorites seven times this season and won four of those games.
• Cincinnati has a record of 4-2 in games when oddsmakers favor them by at least -119 on the moneyline.
• The Reds have a 54.3% chance to win this game based on the implied probability of the moneyline.
• The Marlins have come away with seven wins in the 19 contests they have been listed as the underdogs in this season.
• This season, Miami has come away with a win seven times in 18 chances when named as an underdog of at least -101 or worse on the moneyline.
• The Marlins have an implied victory probability of 50.2% according to the moneyline set for this matchup.

FINAL

CIN 3 · MIA 6

MLB

RUN LINE

TO WIN

TOTAL

Cincinnati Reds

CIN

-1.5

-118

O 8

Miami Marlins

MIA

+1.5

-102

U 8

Reds Recent Betting Performance

• The Reds were the moneyline favorite in four of their last 10 games, and finished 3-1 in those matchups.
• In their last 10 matchups, the Reds and their opponents combined to hit the over on the total six times (all 10 games had set totals).
• The Reds' record against the spread is 6-4-0 over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz paces the Reds with five home runs and 22 runs batted in.
• In all of Major League Baseball, De La Cruz ranks 24th in homers and fifth in RBI.
• De La Cruz carries a five-game hitting streak into this matchup. In his last five games he is hitting .300 with two home runs, four walks and four RBI.
• TJ Friedl is hitting .296 with three doubles, a triple, a home run and eight walks.
• Friedl is 169th in home runs and 84th in RBI among all major league batters this season.
• Friedl has four games in a row with at least one hit. In his last five games he is hitting .409 with a double, a triple, four walks and four RBI.
• Matt McLain is hitting .204 with a double, four home runs and nine walks.
• Gavin Lux's .319 batting average paces his team.
• Lux has recorded at least one hit in six games in a row. In his last 10 games he is batting .455 with three doubles, nine walks and six RBI.

Reds Team Props

Marlins Recent Betting Performance

• The Marlins have played as underdogs in nine of their past 10 games and have gone 3-6 in those contests.
• When it comes to hitting the over, the Marlins and their opponents are 8-2-0 in their last 10 games with a total.
• The Marlins have four wins against the spread in their last 10 chances.

Marlins Recent Stats

Marlins Player Insights

• Otto Lopez is hitting .234 with five doubles, two home runs and nine walks.
• Lopez's home run total places him 116th in the big leagues, and he is 110th in RBI.
• Xavier Edwards has a club-leading .299 batting average.
• Among all major league batters, Edwards ranks 269th in homers and 157th in RBI.
• Wagaman has four doubles, two home runs and six walks while batting .267.
• Kyle Stowers has three doubles, a triple, a home run and 10 walks while batting .296.

Marlins Team Props

Reds vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - Cincinnati Reds vs. Miami Marlins - 04/21/2025

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