Orioles vs. White Sox Prediction, Odds, Picks - September 17

Tyler Wells and Martin Perez will each get the start when the Baltimore Orioles and the Chicago White Sox face off on Wednesday at Rate Field, at 2:10 p.m. ET. The favored Orioles have -125 moneyline odds to win against the underdog White Sox, who are listed at +105. Baltimore is a 1.5-run favorite (at +136 odds). An 8.5-run over/under is set in this contest.

Here is everything you need from a betting perspective on the Orioles-White Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Orioles vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Toronto Blue Jays.

Orioles vs. White Sox Game Information & Odds

• When: Wednesday, September 17, 2025 at 2:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MASN2

Orioles vs. White Sox Prediction

• Score Prediction: White Sox 5, Orioles 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Orioles 52%, White Sox 48%

Orioles vs. White Sox Betting Insights

• This season, the Orioles have won 32 out of the 65 games, or 49.2%, in which they've been favored.
• This season Baltimore has won 21 of its 38 games, or 55.3%, when favored by at least -125 on the moneyline.
• The implied probability of a win from the Orioles, based on the moneyline, is 55.6%.
• The White Sox have been chosen as underdogs in 149 games this year and have walked away with the win 56 times (37.6%) in those games.
• This season, Chicago has been victorious 54 times in 141 chances when named as an underdog of at least +105 or worse on the moneyline.
• The White Sox have an implied victory probability of 48.8% according to the moneyline set for this matchup.

Orioles Recent Betting Performance

• The Orioles played three of their last 10 games as the moneyline favorite, and won all of them.
• Over their last 10 matchups, the Orioles and their opponents combined to hit the over on the total three times (all 10 games had set totals).
• The Orioles have a 4-6-0 record against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson comes into Wednesday's game hitting .272 with 64 RBI, both team-leading marks for the Orioles. He has also launched 16 homers in 2025.
• Henderson ranks 117th in homers and 95th in RBI among all hitters in MLB.
• Jackson Holliday has hit 17 home runs to pace his team.
• Holliday ranks 101st in homers and 130th in RBI among all batters in the majors.
• Jordan Westburg is batting .273 with nine doubles, a triple, 15 home runs and 17 walks.
• Colton Cowser has 12 doubles, 15 home runs and 22 walks while batting .199.

Orioles Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in nine of their past 10 games and won three of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 4-6-0 in their last 10 games with a total.
• The White Sox have won six of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is hitting .229 with 31 doubles, two triples, 14 home runs and 50 walks.
• Among all hitters in the majors, Vargas' home run total is 143rd and his RBI tally is 140th.
• Andrew Benintendi has launched a team-best 20 home runs.
• Benintendi ranks 70th among all batters in the majors in home runs, and 99th in RBI.
• Lenyn Sosa has accumulated a club-leading .262 batting average, while leading the White Sox in home runs (20) and runs batted in (70).
• Chase Meidroth has 15 doubles, five home runs and 44 walks while hitting .270.

White Sox Team Props

Orioles vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago White Sox

Baltimore Orioles