Orioles vs. Astros Prediction, Odds, Picks - August 23

Gunnar Henderson and the Baltimore Orioles take the field against Jeremy Pena and the Houston Astros on Saturday at 7:05 p.m. ET, in the third of a four-game series at Oriole Park at Camden Yards. The favored Orioles have -120 moneyline odds against the underdog Astros, who are listed at +101. Baltimore is a 1.5-run favorite (at +168 odds). A 9-run total has been listed in this matchup.

Take a look at everything you need from a betting perspective on the Orioles-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Orioles Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and Baltimore Orioles.

Orioles vs. Astros Game Information & Odds

• When: Saturday, August 23, 2025 at 7:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and SCHN

Orioles vs. Astros Prediction

• Score Prediction: Orioles 5, Astros 4
• Total Prediction: Under 9 runs
• Win Probabilities: Orioles 51%, Astros 49%

Orioles vs. Astros Betting Insights

• The Orioles have entered the game as favorites 59 times this season and won 27, or 45.8%, of those games.
• Baltimore has a record of 22-25 in games when sportsbooks favor them by at least -120 on the moneyline.
• The implied probability of a win from the Orioles, based on the moneyline, is 54.5%.
• The Astros have come away with 25 wins in the 42 contests they have been listed as the underdogs in this season.
• Houston has a mark of 18-13 in contests where bookmakers favor it by +101 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 49.8% chance of pulling out a win.

Orioles Recent Betting Performance

• The Orioles have been named the moneyline favorite by bookmakers only one time in the last 10 games, and lost that matchup.
• In their last 10 matchups, the Orioles and their opponents combined to hit the over on the run total five times (all 10 games had set totals).
• The Orioles have put together an 8-2-0 record against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Henderson leads the Orioles with 15 home runs and 57 runs batted in, while racking up a team-high batting average of .281.
• Among all MLB hitters, Henderson ranks 28th in batting average, 38th in on-base percentage, and 46th in slugging.
• Henderson carries a four-game hitting streak into this matchup. In his last five games he is hitting .300 with a triple, a home run, three walks and four RBIs.
• Jackson Holliday has shown off his power as he leads his team with 15 home runs.
• Holliday ranks 103rd in home runs in baseball, and 125th in RBI.
• Holliday carries a three-game streak with at least one hit into this matchup. In his last five games he is hitting .263 with a double, seven walks and two RBIs.
• Ryan Mountcastle has 14 doubles, four home runs and 11 walks while hitting .256.
• Mountcastle will look to build on his eight-game hitting in this game. During his last 10 games he is hitting .300 with a double, a home run, three walks and four RBIs.
• Colton Cowser is hitting .211 with 11 doubles, 10 home runs and 16 walks.
• Cowser is riding a three-game hitting streak into this one. During his last five outings he is hitting .190 with a double, a home run, three walks and two RBIs.

Orioles Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in three of their past 10 games and have gone 1-2 in those contests.
• In their last 10 games with a total, the Astros and their opponents have failed to hit the over three times.
• The Astros have four wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has a team-high 22 home runs.
• In all of the big leagues, Altuve is 36th in home runs and 55th in RBI.
• Pena is batting .307 to lead the lineup.
• Pena is currently 113th in home runs and 125th in RBI in the big leagues.
• Yainer Diaz has 16 doubles, a triple, 18 home runs and 18 walks while hitting .254.
• Christian Walker has recorded a team-high 70 runs batted in.

Astros Team Props

Astros vs. Orioles Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Baltimore Orioles

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