Mariners vs. Padres Prediction, Odds, Picks - August 27

Manny Machado and the San Diego Padres will take the field on Wednesday at T-Mobile Park against Bryan Woo, who is the named starter for the Seattle Mariners. First pitch is set for 4:10 p.m. ET. The Mariners are the favorite in this one, at -114, while the underdog Padres have -106 odds to win. San Diego is favored on the run line (-1.5). The contest's total has been set at 8 runs.

Here is everything you need to know from a betting perspective on the Mariners-Padres game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Dodgers vs. Padres Highlights | MLB on FOX

Check out the best moments between the Los Angeles Dodgers and San Diego Padres.

Mariners vs. Padres Game Information & Odds

• When: Wednesday, August 27, 2025 at 4:10 p.m. ET
• Where: T-Mobile Park in Seattle, Washington
• How to watch on TV: MLB Network, ROOT Sports NW, and SDPA

Mariners vs. Padres Prediction

• Score Prediction: Mariners 5, Padres 4
• Total Prediction: Under 8 runs
• Win Probabilities: Mariners 53%, Padres 47%

Mariners vs. Padres Betting Insights

• The Mariners have won 50, or 54.9%, of the 91 games they've played as favorites this season.
• Seattle has a record of 47-39, a 54.7% win rate, when favored by -114 or more by oddsmakers this season.
• The moneyline for this contest implies a 53.3% chance of a victory for the Mariners.
• The Padres have been chosen as underdogs in 62 games this year and have walked away with the win 32 times (51.6%) in those games.
• This year, San Diego has won 29 of 59 games when listed as at least -106 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 51.5% chance of coming away with a victory in the contest.

Mariners Recent Betting Performance

• The Mariners played as the moneyline favorite in seven of their last 10 games, and went 3-4 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Mariners and their opponents combined to go over the run total seven times.
• The Mariners have put together a 3-7-0 record against the spread over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh leads the Mariners with 50 home runs and 107 runs batted in.
• Of all batters in the majors, Raleigh's home run total ranks him first, and his RBI tally puts him second.
• Julio Rodriguez is hitting .261 with 24 doubles, four triples, 25 home runs and 34 walks.
• Rodriguez ranks 24th in home runs in MLB, and 35th in RBI.
• Rodriguez heads into this matchup looking for his fourth game in a row with a hit. During his last five outings he is hitting .222 with two walks and two RBIs.
• Josh Naylor leads the Mariners with a .286 batting average.
• Naylor will look to build on his five-game hitting in this game. In his last five games he is batting .389 with a double, a home run, a walk and four RBIs.
• Eugenio Suarez is hitting .235 with 23 doubles, 41 home runs and 37 walks.

Mariners Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in five of their past 10 games and have gone 3-2 in those contests.
• In their last 10 games with a total, the Padres and their opponents are 6-4-0 when it comes to hitting the over.
• The Padres have a record of 6-4-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. has 26 doubles, two triples, 18 home runs and 79 walks while batting .263.
• Tatis' home run total places him 70th in the majors, and he is 101st in RBI.
• Machado has hit 21 home runs with 78 RBI while hitting .290. Those numbers are pace the clubhouse.
• Machado ranks 46th among all hitters in the big leagues in home runs, and 21st in RBI.
• Luis Arraez is hitting .283 with 29 doubles, four triples, six home runs and 26 walks.
• Xander Bogaerts has 29 doubles, 10 home runs and 48 walks while hitting .262.

Padres Team Props

Athletics vs. Mariners Highlights | MLB on FOX

Check out the best moments between the Athletics and the Seattle Mariners.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Seattle Mariners

San Diego Padres