Guardians vs. Twins Prediction, Odds, Picks - August 2

The Cleveland Guardians and Jose Ramirez will take on the Minnesota Twins and Ryan Jeffers at Progressive Field on Saturday, with the first pitch at 4:10 p.m. ET. The Guardians are listed as -159 moneyline favorites in this matchup against the Twins (+134). Cleveland (-1.5) is favored on the run line. The total is 7 runs for the game (with -117 odds to go over and -104 odds on the under).

Here's everything you need to know from a betting perspective on the Guardians-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and Cleveland Guardians.

Guardians vs. Twins Game Information & Odds

• When: Saturday, August 2, 2025 at 4:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and MNNT

Guardians vs. Twins Prediction

• Score Prediction: Guardians 5, Twins 4
• Total Prediction: Over 7 runs
• Win Probabilities: Guardians 53%, Twins 47%

Guardians vs. Twins Betting Insights

• The Guardians have entered the game as favorites 45 times this season and won 28, or 62.2%, of those games.
• Cleveland is 8-2 this season when entering a game favored by -159 or more on the moneyline.
• The oddsmakers' moneyline implies a 61.4% chance of a victory for the Guardians.
• The Twins have been underdogs in 37 games this season and have come away with the win 14 times (37.8%) in those contests.
• This year, Minnesota has won two of seven games when listed as at least +134 or worse on the moneyline.
• The Twins have an implied victory probability of 42.7% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians went 5-2 across the seven games they were moneyline favorites in their last 10 matchups.
• Over their last 10 outings, the Guardians and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Guardians have gone 5-5-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez's 21 home runs and 57 RBI both lead the Guardians, in addition to his team-high .298 average.
• Among all hitters in MLB, Ramirez is 19th in homers and 53rd in RBI.
• Ramirez carries a three-game hitting streak into this matchup. During his last five outings he is batting .286 with a double, two walks and an RBI.
• Steven Kwan is batting .287 with 20 doubles, a triple, nine home runs and 40 walks.
• Of all major league hitters, Kwan ranks 155th in homers and 154th in RBI.
• Kwan carries a nine-game streak with at least one hit into this contest. In his last 10 outings he is hitting .279 with three home runs, four walks and six RBIs.
• Carlos Santana is hitting .230 with eight doubles, 11 home runs and 47 walks.
• Santana has at least one base hit in four games in a row. During his last five outings he is hitting .316 with a double, two walks and three RBIs.
• Kyle Manzardo is hitting .240 with 13 doubles, two triples, 18 home runs and 32 walks.
• Manzardo has recorded at least one hit in 10 games in a row. In his last 10 outings he is hitting .455 with two doubles, three home runs, four walks and 11 RBIs.

Guardians Team Props

Twins Recent Betting Performance

• The Twins have played as underdogs in five of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Twins and their opponents are 4-5-1 when it comes to hitting the over.
• The Twins have four wins against the spread in their last 10 chances.

Twins Recent Stats

Twins Player Insights

• Trevor Larnach is batting .242 with 15 doubles, a triple, 13 home runs and 37 walks.
• Among all hitters in MLB, Larnach is 98th in homers and 114th in RBI.
• Jeffers is batting .255 with 19 doubles, seven home runs and 34 walks.
• Jeffers ranks 199th overall in homers and 178th in RBI this season.
• Brooks Lee is hitting .253 with 10 doubles, 10 home runs and 16 walks.
• Kody Clemens is hitting .213 with six doubles, three triples, 12 home runs and 17 walks.

Twins Team Props

Twins vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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