Guardians vs. Reds Prediction, Odds, Picks - June 11

Jose Ramirez and the Cleveland Guardians will try to beat Jake Fraley and the Cincinnati Reds when the teams meet on Wednesday at 1:10 p.m. ET. The Reds are -106 moneyline underdogs for this matchup against the favorite Guardians (-113). Cincinnati is a 1.5-run favorite (at +152 odds). An 8.5-run total has been set in the matchup.

Here's everything you need from a betting perspective on the Guardians-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Cleveland Guardians.

Guardians vs. Reds Game Information & Odds

• When: Wednesday, June 11, 2025 at 1:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSOH

Guardians vs. Reds Prediction

• Score Prediction: Guardians 5, Reds 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Guardians 52%, Reds 48%

Guardians vs. Reds Betting Insights

• The Guardians have been favorites in 25 games this season and won 15 (60%) of those contests.
• Cleveland has a record of 14-8, a 63.6% win rate, when favored by -113 or more by sportsbooks this season.
• The implied probability of a win from the Guardians, based on the moneyline, is 53.1%.
• The Reds have been chosen as underdogs in 38 games this year and have walked away with the win 20 times (52.6%) in those games.
• Cincinnati has a mark of 18-16 in contests where oddsmakers favor it by -106 or worse on the moneyline.
• The Reds have an implied victory probability of 51.5% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians went 3-2 over the five games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Guardians and their opponents combined to go over the run total three times.
• The Guardians' record against the spread is 6-4-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez paces the Guardians in home runs (12), runs batted in (32) and has racked up a team-best batting average of .332.
• Ramirez is 30th in home runs and 69th in RBI among all hitters in the majors.
• Ramirez takes a hitting streak of 10 games into this matchup. In his last 10 outings he is hitting .405 with a double, three home runs, six walks and five RBIs.
• Steven Kwan is hitting .305 with 14 doubles, five home runs and 23 walks.
• Kwan is 162nd in homers and 155th in RBI among all major league hitters this season.
• Carlos Santana is batting .251 with six doubles, seven home runs and 32 walks.
• Kyle Manzardo is batting .203 with six doubles, two triples, 11 home runs and 23 walks.

Guardians Team Props

Reds Recent Betting Performance

• In eight games over the last 10 matchups when set as underdogs by sportsbooks, the Reds had a record of 5-3.
• In their last 10 games with a total, the Reds and their opponents have failed to hit the over six times.
• The Reds have won six of their last 10 games against the spread.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz leads the Reds in home runs (12) and runs batted in (43).
• De La Cruz is 30th in homers and 18th in RBI among all hitters in the majors.
• TJ Friedl has a club-leading .294 batting average.
• Friedl ranks 132nd overall in homers and 133rd in RBI this season.
• Gavin Lux has 14 doubles, a triple, two home runs and 27 walks while hitting .280.
• Jose Trevino is batting .304 with 14 doubles, four home runs and seven walks.

Reds Team Props

Reds vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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