Guardians vs. Blue Jays Prediction, Odds, Picks - May 4

Bowden Francis takes the mound for the Toronto Blue Jays on Sunday at Rogers Centre against Bo Naylor and the Cleveland Guardians. First pitch is at 1:37 p.m. ET. Oddsmakers list the Guardians as -113 favorites on the moneyline, while giving the underdog Blue Jays -106 moneyline odds. Cleveland is a 1.5-run favorite (at +144 odds). The over/under is 8.5 runs for this game.

Here's everything you need to know from a betting perspective on the Guardians-Blue Jays game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Toronto Blue Jays.

Guardians vs. Blue Jays Game Information & Odds

• When: Sunday, May 4, 2025 at 1:37 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: SNET and CLEG

Guardians vs. Blue Jays Prediction

• Score Prediction: Blue Jays 5, Guardians 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Guardians 53%, Blue Jays 47%

Guardians vs. Blue Jays Betting Insights

• The Guardians have been favorites in 12 games this season and won nine (75%) of those contests.
• Cleveland has a record of 9-2 in games when oddsmakers favor them by at least -113 on the moneyline.
• The sportsbooks' moneyline implies a 53.1% chance of a victory for the Guardians.
• The Blue Jays have been victorious in nine, or 42.9%, of the 21 contests they have been chosen as underdogs in this season.
• Toronto has a mark of 7-11 in contests where sportsbooks favor it by -106 or worse on the moneyline.
• The moneyline set for this matchup implies the Blue Jays have a 51.5% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians have been listed as the moneyline favorite by oddsmakers only two times in the last 10 games, and split those matchups.
• In their last 10 outings, the Guardians and their opponents combined to hit the over on the total five times (all 10 games had set totals).
• The Guardians have a 4-6-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan paces the Guardians with a team-best batting average of .328.
• In all of Major League Baseball, Kwan is 88th in home runs and 75th in RBI.
• Kwan carries a two-game hitting streak into this matchup. In his last five games he is hitting .238 with a double and a walk.
• Jose Ramirez is hitting .274 with five doubles, five home runs and nine walks.
• Ramirez ranks 55th in homers and 75th in RBI among all hitters in the majors.
• Ramirez enters this game looking for his fourth game in a row with a hit. In his last five games he is batting .333 with a double and an RBI.
• Kyle Manzardo has put up a team-high eight home runs and 20 runs batted in.
• Carlos Santana is hitting .225 with two doubles, three home runs and 13 walks.

Guardians Team Props

Blue Jays Recent Betting Performance

• The Blue Jays have played as underdogs in six of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Blue Jays and their opponents are 4-6-0 in their last 10 games with a total.
• The Blue Jays are 4-6-0 ATS over their last 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. paces the Blue Jays with four home runs and runs batted in, driving in 17.
• Among all batters in the big leagues, Guerrero ranks 88th in home runs and 55th in RBI.
• Guerrero has collected a hit in six games in a row. During his last 10 games he is hitting .231 with three home runs, two walks and seven RBI.
• George Springer has a club-high .322 batting average.
• Springer is 123rd in homers and 120th in RBI among all batters in the big leagues.
• Bo Bichette is batting .284 with 10 doubles, a home run and six walks.
• Andres Gimenez has four doubles, three home runs and 10 walks while hitting .179.

Blue Jays Team Props

Guardians vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Toronto Blue Jays

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