Dodgers vs. Diamondbacks Prediction, Odds, Picks - September 25

A pair of hot hitters, Shohei Ohtani and Geraldo Perdomo, will try to keep it going when the Los Angeles Dodgers play the Arizona Diamondbacks on Thursday at 3:40 p.m. ET, at Chase Field. The favored Dodgers have -164 moneyline odds against the underdog Diamondbacks, who are listed at +137. Los Angeles is the favorite on the run line (-1.5 with -102 odds). The total is 8.5 runs for the matchup (with -108 odds on the over and -112 odds on the under).

Here's everything you need from a betting perspective on the Dodgers-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Diamondback vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the Milwaukee Brewers.

Dodgers vs. Diamondbacks Game Information & Odds

• When: Thursday, September 25, 2025 at 3:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and SportsNet LA

Dodgers vs. Diamondbacks Prediction

• Score Prediction: Diamondbacks 4, Dodgers 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Dodgers 51%, Diamondbacks 49%

Dodgers vs. Diamondbacks Betting Insights

• The Dodgers have been favorites in 140 games this season and won 80 (57.1%) of those contests.
• Los Angeles has a record of 50-38 in games when oddsmakers favor them by at least -164 on the moneyline.
• The bookmakers' moneyline implies a 62.1% chance of a victory for the Dodgers.
• The Diamondbacks have won in 34, or 50%, of the 68 contests they have been named as odds-on underdogs this year.
• This season, Arizona has come away with a win eight times in 14 chances when named as an underdog of at least +137 or worse on the moneyline.
• The Diamondbacks have an implied victory probability of 42.2% according to the moneyline set by oddsmakers for this matchup.

Dodgers Recent Betting Performance

• The Dodgers have a 6-4 record from the 10 games they were moneyline favorites over their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Dodgers and their opponents combined to go over the run total five times.
• The Dodgers have a 5-5-0 record against the spread over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• The Dodgers' best power option comes in the form of Ohtani and his 53-dinger 99-RBI season, both team highs.
• Ohtani ranks third in homers and 13th in RBI among all hitters in the majors.
• Mookie Betts has 23 doubles, two triples, 20 home runs and 60 walks while batting .262.
• Betts ranks 79th in home runs and 49th in RBI among all major league batters this year.
• Betts carries a two-game streak with at least one hit into this matchup. In his last five games he is hitting .316 with a double, a home run, two walks and two RBIs.
• Freddie Freeman has racked up a team-best batting average of .291.
• Freeman is on a four-game hitting streak entering this contest. In his last five games he is hitting .200 with a walk and an RBI.
• Andy Pages has 27 doubles, a triple, 26 home runs and 28 walks while hitting .276.

Dodgers Team Props

Diamondbacks Recent Betting Performance

• The Diamondbacks have played as underdogs in five of their past 10 games and have gone 4-1 in those contests.
• When it comes to hitting the over, the Diamondbacks and their opponents are 5-3-2 in their last 10 games with a total.
• The Diamondbacks have won seven of their last 10 games against the spread.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• The Diamondbacks are led in runs batted in by Perdomo with a mark of 98, he also leads the team in hitting, posting an average of .290.
• Among all hitters in the big leagues, Perdomo ranks 89th in home runs and 14th in RBI.
• Corbin Carroll has put his power on display as he paces his team with 31 home runs.
• Carroll ranks 17th in home runs and 35th in RBI among all MLB hitters this season.
• Ketel Marte is batting .284 with 27 doubles, 26 home runs and 63 walks.
• Gabriel Moreno has 12 doubles, a triple, nine home runs and 27 walks while hitting .288.

Diamondbacks Team Props

Dodgers lose Ohtani gem game, Is Baseball in a good position right now? | The Herd

The Los Angeles Dodgers lost a game where Shohei Ohtani performed extremely well, as the New York Yankees and Seattle Mariners clinched playoff spots. Colin Cowherd discusses the state of baseball and if things are trending in the right direction.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Arizona Diamondbacks

Los Angeles Dodgers