Cubs vs. Royals Prediction, Odds, Picks - July 21

Ryan Brasier and Noah Cameron are the projected starters when the Chicago Cubs and Kansas City Royals face off on Monday at Wrigley Field. The Cubs are -150 moneyline favorites in this matchup against the Royals (+125). Chicago is the run-line favorite (-1.5). The matchup's over/under is listed at 7.5 runs.

Here's everything you need to know from a betting perspective on the Cubs-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Royals Game Information & Odds

• When: Monday, July 21, 2025 at 8:05 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MLB Network, MARQ, and FDSKC

Cubs vs. Royals Prediction

• Score Prediction: Cubs 5, Royals 3
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cubs 66%, Royals 34%

Cubs vs. Royals Betting Insights

• The Cubs have entered the game as favorites 67 times this season and won 47, or 70.1%, of those games.
• This season Chicago has won 26 of its 33 games, or 78.8%, when favored by at least -150 on the moneyline.
• The Cubs have a 60% chance to win this game based on the implied probability of the moneyline.
• The Royals have come away with 28 wins in the 61 contests they have been listed as the underdogs in this season.
• This season, Kansas City has been victorious 10 times in 19 chances when named as an underdog of at least +125 or longer on the moneyline.
• The Royals have an implied victory probability of 44.4% according to the moneyline set for this matchup.

Cubs Recent Betting Performance

• The Cubs have a 4-1 record from the five games they were moneyline favorites over their last 10 matchups.
• In their last 10 matchups, the Cubs and their opponents combined to go over the total three times (all 10 games had set totals).
• The Cubs' ATS record is 6-4-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is batting .279 with 19 doubles, four triples, 18 home runs and 62 walks.
• Tucker ranks 28th in home runs and 28th in RBI among all hitters in MLB.
• Pete Crow-Armstrong's 26 home runs lead his team.
• Including all MLB hitters, Crow-Armstrong is sixth in home runs and ninth in RBI.
• Crow-Armstrong has four games in a row with at least one hit. During his last five outings he is batting .286 with three doubles, a home run and two RBIs.
• Seiya Suzuki paces the Cubs in home runs (26) and runs batted in (80).
• Nico Hoerner has a club-leading .288 batting average.
• Hoerner takes a three-game streak with at least one hit into this one. In his last five games he is hitting .316 with a triple, a walk and an RBI.

Cubs Team Props

Royals Recent Betting Performance

• In three games over the last 10 matchups when set as underdogs by oddsmakers, the Royals had a record of 1-2.
• The Royals and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Royals have a record of 4-6-0 ATS over their last 10 games.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. is batting .289 with 33 doubles, three triples, 14 home runs and 31 walks, while getting on base at a rate of .341.
• Among all batters in MLB, Witt's home run total ranks 62nd and his RBI tally is 45th.
• Maikel Garcia's .292 batting average paces his team.
• Garcia is currently 155th in homers and 99th in RBI in the major leagues.
• Vinnie Pasquantino has been solid source of run production for the Royals with 15 long balls and 57 runs batted in.
• Salvador Perez has swatted a team-leading 15 home runs.

Royals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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