Cubs vs. Reds Prediction, Odds, Picks - September 19

Nico Hoerner and Elly De La Cruz are the hottest hitters on the Chicago Cubs and Cincinnati Reds, who play on Friday at Great American Ball Park, at 6:40 p.m. ET. The favored Cubs have -112 moneyline odds to win against the underdog Reds, who are listed at -107. Chicago (-1.5) is the favorite on the run line. An 8-run total has been listed for this game.

Check out everything you need from a betting perspective on the Cubs-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Reds Highlights | MLB on FOX

Enjoy the best moments between the Chicago Cubs and Cincinnati Reds.

Cubs vs. Reds Game Information & Odds

• When: Friday, September 19, 2025 at 6:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: MLB Network, FDSOH, and MARQ

Cubs vs. Reds Prediction

• Score Prediction: Reds 5, Cubs 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cubs 50%, Reds 50%

Cubs vs. Reds Betting Insights

• The Cubs have been favorites in 110 games this season and won 70 (63.6%) of those contests.
• This season Chicago has won 69 of its 109 games, or 63.3%, when favored by at least -112 on the moneyline.
• The Cubs have a 52.8% chance to win this game based on the implied probability of the moneyline.
• The Reds have been chosen as underdogs in 82 games this year and have walked away with the win 40 times (48.8%) in those games.
• This season, Cincinnati has been victorious 37 times in 77 chances when named as an underdog of at least -107 or worse on the moneyline.
• The moneyline set for this matchup implies the Reds have a 51.7% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite in six of their last 10 games, and they went 5-1 in those matchups.
• In their last 10 matchups, the Cubs and their opponents combined to hit the over three times (all 10 of the games had set totals).
• The Cubs are 8-2-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Hoerner paces the Cubs with a team-best batting average of .301.
• Of all batters in the majors, Hoerner's home run total ranks him 270th, and his RBI tally puts him 117th.
• Pete Crow-Armstrong's 29 home runs lead his team.
• Crow-Armstrong ranks 22nd in home runs in MLB, and 24th in RBI.
• Ian Happ has 28 doubles, 23 home runs and 85 walks while batting .241.
• Seiya Suzuki has put up 91 runs batted in to lead his team.

Cubs Team Props

Reds Recent Betting Performance

• In five games over the last 10 matchups when set as underdogs by oddsmakers, the Reds had a record of 3-2.
• When it comes to hitting the over, the Reds and their opponents are 3-7-0 in their last 10 games with a total.
• The Reds have a record of 5-5-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• De La Cruz paces the Reds in home runs (19) and runs batted in (82).
• Among all hitters in the big leagues, De La Cruz's home run total is 81st and his RBI tally is 33rd.
• TJ Friedl has 20 doubles, two triples, 12 home runs and 76 walks while hitting .257.
• Friedl ranks 164th among all batters in the big leagues in home runs, and 176th in RBI.
• Spencer Steer is batting .240 with 20 doubles, two triples, 18 home runs and 45 walks.
• Austin Hays is hitting .269 with 16 doubles, five triples, 15 home runs and 29 walks.

Reds Team Props

Cubs vs. Reds Highlights | MLB on FOX

Enjoy the best moments between the Chicago Cubs and Cincinnati Reds.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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