Cardinals vs. Rockies Prediction, Odds, Picks - July 22

The St. Louis Cardinals and Nolan Arenado head into the second of a three-game series against Jordan Beck and the Colorado Rockies on Tuesday at Coors Field. The Rockies are listed as +140 moneyline underdogs for this matchup with the Cardinals (-167). St. Louis is a 1.5-run favorite (at -110 odds). The over/under for the contest has been listed at 12 runs.

Here is everything you need to know from a betting perspective on the Cardinals-Rockies game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Rockies Game Information & Odds

• When: Tuesday, July 22, 2025 at 8:40 p.m. ET
• Where: Coors Field in Denver, Colorado
• How to watch on TV: COLR and FDSMW

Cardinals vs. Rockies Prediction

• Score Prediction: Cardinals 8, Rockies 7
• Total Prediction: Over 12 runs
• Win Probabilities: Cardinals 53%, Rockies 47%

Cardinals vs. Rockies Betting Insights

• The Cardinals have won 26, or 56.5%, of the 46 games they've played as favorites this season.
• St. Louis is undefeated in five games this season when favored by -167 or more on the moneyline.
• The moneyline for this contest implies a 62.5% chance of a victory for the Cardinals.
• The Rockies have won in 23, or 24%, of the 96 contests they have been named as odds-on underdogs this year.
• This year, Colorado has won 18 of 80 games when listed as at least +140 or worse on the moneyline.
• The Rockies have an implied victory probability of 41.7% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

• The Cardinals were the moneyline favorite for seven of their last 10 games, and went 4-3 in those matchups.
• In their last 10 matchups (all had set totals), the Cardinals combined with their opponents to hit the over on the run total six times.
• The Cardinals' record against the spread is 5-5-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan paces the Cardinals with a team-high batting average of .293.
• Donovan ranks 157th in homers and 124th in RBI among all hitters in baseball.
• Nolan Arenado is hitting .244 with 15 doubles, a triple, 10 home runs and 26 walks.
• Arenado is 131st in home runs in the majors, and 89th in RBI.
• Alec Burleson is batting .289 with 17 doubles, 12 home runs and 23 walks.
• Willson Contreras has hit 13 home runs with 57 runs batted in. Both are team-highs.
• Contreras is riding a two-game hitting streak into this one. In his last five games he is batting .316 with three doubles, a home run, a walk and four RBIs.

Cardinals Team Props

Rockies Recent Betting Performance

• The Rockies have played as underdogs in 10 of their past 10 games and have gone 3-7 in those contests.
• In their last 10 games with a total, the Rockies and their opponents have failed to hit the over six times.
• Over their last 10 games, the Rockies are 4-6-0 against the spread.

Rockies Recent Stats

Rockies Player Insights

• Hunter Goodman leads the lineup with a batting average of .278, while pacing the Rockies in home runs, with 18 and runs batted in with 56.
• Goodman ranks 29th in homers and 38th in RBI among all batters in the majors.
• Jordan Beck is batting .271 with 18 doubles, five triples, 11 home runs and 23 walks.
• Beck is currently 111th in home runs and 161st in RBI in the major leagues.
• Mickey Moniak is hitting .271 with 11 doubles, six triples, 14 home runs and 16 walks.
• Ryan McMahon has 15 doubles, a triple, 15 home runs and 47 walks while hitting .218.

Rockies Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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