Brewers vs. Reds Prediction, Odds, Picks - September 27

TJ Friedl and the Cincinnati Reds will hit the field on Saturday at American Family Field against Robert Gasser, who is starting for the Milwaukee Brewers. First pitch is set for 7:15 p.m. ET for the second game of a three-game series. Bookmakers list the Brewers as -132 moneyline favorites, while giving the underdog Reds +112 moneyline odds. Milwaukee (-1.5) is the favorite on the run line. The contest's over/under is set at 8 runs.

Here is everything you need from a betting perspective on the Brewers-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Reds Game Information & Odds

• When: Saturday, September 27, 2025 at 7:15 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: FOX

Brewers vs. Reds Prediction

• Score Prediction: Brewers 5, Reds 4
• Total Prediction: Over 8 runs
• Win Probabilities: Brewers 56%, Reds 44%

Brewers vs. Reds Betting Insights

• The Brewers have been favorites in 95 games this season and won 59 (62.1%) of those contests.
• Milwaukee has a record of 44-18 in games when oddsmakers favor them by at least -132 on the moneyline.
• The sportsbooks' moneyline implies a 56.9% chance of a victory for the Brewers.
• The Reds have come away with 42 wins in the 84 contests they have been listed as the underdogs in this season.
• This year, Cincinnati has won 19 of 47 games when listed as at least +112 or worse on the moneyline.
• The Reds have an implied victory probability of 47.2% according to the moneyline set by sportsbooks for this matchup.

Brewers Recent Betting Performance

• The Brewers went 4-5 across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Brewers and their opponents combined to hit the over on the total four times (all 10 games had set totals).
• The Brewers have gone 4-6-0 against the spread over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Brice Turang is batting .287 with 26 doubles, two triples, 18 home runs and 63 walks.
• Among all batters in baseball, Turang is 104th in homers and 56th in RBI.
• Turang has collected a hit in two straight games. During his last five outings he is batting .313 with two walks and two RBIs.
• Christian Yelich has shown off his power as he leads his team with 29 home runs and 102 runs batted in.
• Yelich ranks 33rd in homers and 12th in RBI among all batters in the majors.
• Yelich carries a four-game streak with at least one hit into this matchup. In his last five games he is batting .235 with a double, three walks and two RBIs.
• William Contreras is batting .260 with 28 doubles, 17 home runs and 84 walks.
• Jackson Chourio is hitting .269 with 34 doubles, four triples, 20 home runs and 30 walks.

Brewers Team Props

Reds Recent Betting Performance

• The Reds have been underdogs twice in the last 10 games and won both contests.
• The Reds and their opponents have combined to hit the over just once in their last 10 games with a total.
• The Reds have four wins against the spread in their last 10 chances.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz paces the Reds with 21 long balls and runs batted in, driving in 85.
• Among all hitters in the majors, De La Cruz is 71st in homers and 37th in RBI.
• Friedl is batting .261 with 22 doubles, two triples, 13 home runs and 80 walks.
• Friedl is 159th overall in homers and 176th in RBI this year.
• Spencer Steer has 21 home runs, best in the lineup.
• Austin Hays is hitting .266 with 16 doubles, five triples, 15 home runs and 29 walks.

Reds Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Milwaukee Brewers

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