Brewers vs. Padres Prediction, Odds, Picks - September 22

The Milwaukee Brewers and San Diego Padres will play on Monday at PETCO Park, at 9:40 p.m. ET, with Brice Turang and Fernando Tatis Jr. among those expected to produce at the plate. The Padres are listed as -108 moneyline underdogs for this matchup against the Brewers (-111). Milwaukee is a 1.5-run favorite (at +162 odds). The matchup's total is set at 7 runs.

Take a look at everything you need from a betting perspective on the Brewers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Padres Game Information & Odds

• When: Monday, September 22, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSWI

Brewers vs. Padres Prediction

• Score Prediction: Brewers 5, Padres 4
• Total Prediction: Over 7 runs
• Win Probabilities: Brewers 51%, Padres 49%

Brewers vs. Padres Betting Insights

• The Brewers have entered the game as favorites 92 times this season and won 59, or 64.1%, of those games.
• Milwaukee has entered 90 games this season favored by -111 or more and is 58-32 in those contests.
• The implied probability of a win from the Brewers, based on the moneyline, is 52.6%.
• The Padres have been victorious in 33, or 49.3%, of the 67 contests they have been chosen as underdogs in this season.
• San Diego has a win-loss record of 31-34 when favored by -108 or worse by sportsbooks this year.
• The moneyline set for this matchup implies the Padres have a 51.9% chance of coming away with a victory in the contest.

Brewers Recent Betting Performance

• The Brewers were favored on the moneyline in each of their last 10 games, and they finished 6-4 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Brewers and their opponents combined to go over the run total six times.
• The Brewers' record against the spread is 4-6-0 over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• William Contreras is batting .265 with 28 doubles, 17 home runs and 83 walks.
• Contreras ranks 108th in homers and 58th in RBI among all batters in the majors.
• Contreras carries a two-game hitting streak into this matchup. During his last five outings he is batting .313 with two doubles, four walks and two RBIs.
• Turang is batting .286 with 26 doubles, two triples, 18 home runs and 61 walks.
• Turang is 97th in home runs and 55th in RBI on the year.
• Christian Yelich leads the Brewers with 29 home runs and 100 runs batted in.
• Jackson Chourio has 34 doubles, four triples, 20 home runs and 28 walks while batting .275.

Brewers Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in three of their past 10 games and won one of those contests.
• When it comes to hitting the over, the Padres and their opponents are 5-5-0 in their last 10 games with a total.
• Over their last 10 games, the Padres are 5-5-0 against the spread.

Padres Recent Stats

Padres Player Insights

• Tatis has 27 doubles, two triples, 23 home runs and 88 walks while hitting .267.
• Among all hitters in the majors, Tatis is 56th in homers and 94th in RBI.
• Tatis has collected a hit in five games in a row. In his last five games he is hitting .381 with a home run, two walks and an RBI.
• Manny Machado been a consistent power bat this season, as he leads his team with 26 home runs and 93 runs batted in.
• Among all major league hitters, Machado is 39th in homers and 21st in RBI.
• Luis Arraez has racked up a team-high batting average of .287.
• Ramon Laureano is batting .282 with 26 doubles, two triples, 24 home runs and 34 walks.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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