Astros vs. Mariners Prediction, Odds, Picks - September 20

George Kirby takes the mound for the Seattle Mariners on Saturday at Daikin Park against Yainer Diaz and the Houston Astros. First pitch is at 7:10 p.m. ET. The Astros are favored in this one, at -111, while the underdog Mariners have -109 odds to upset. Seattle is a 1.5-run favorite (at +154 odds). The over/under for the game is set at 7.5 runs.

Here's everything you need to know from a betting perspective on the Astros-Mariners game, regarding the run line, moneyline and total, plus expert picks.

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Mariners vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Seattle Mariners and the Houston Astros.

Astros vs. Mariners Game Information & Odds

• When: Saturday, September 20, 2025 at 7:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and ROOT Sports NW

Astros vs. Mariners Prediction

• Score Prediction: Astros 5, Mariners 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 52%, Mariners 48%

Astros vs. Mariners Betting Insights

• This season, the Astros have won 52 out of the 99 games, or 52.5%, in which they've been favored.
• Houston has a record of 52-47, a 52.5% win rate, when favored by -111 or more by sportsbooks this season.
• The moneyline for this contest implies a 52.6% chance of a victory for the Astros.
• The Mariners have been victorious in 22, or 47.8%, of the 46 contests they have been chosen as underdogs in this season.
• This season, Seattle has been victorious 20 times in 42 chances when named as an underdog of at least -109 or worse on the moneyline.
• The Mariners have an implied victory probability of 52.2% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros have a 2-2 record over the four games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups -- all had a set run total -- the Astros and their opponents combined to go over the total four times.
• The Astros' record against the spread is 7-3-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve leads the Astros with 26 homers on the year. He's also hitting .261 with 74 RBI.
• Altuve ranks 39th in homers and 64th in RBI among all batters in baseball.
• Jeremy Pena has a club-best .303 batting average.
• Pena ranks 120th in home runs and 122nd in RBI in the majors.
• Diaz is hitting .256 with 23 doubles, a triple, 19 home runs and 20 walks.
• Carlos Correa is batting .276 with 27 doubles, 13 home runs and 41 walks.
• Correa takes a four-game streak with at least one hit into this one. During his last five outings he is hitting .300 with two doubles and a walk.

Astros Team Props

Mariners Recent Betting Performance

• The Mariners have been underdogs twice in the last 10 games and split those matchups 1-1.
• In their last 10 games with a total, the Mariners and their opponents have failed to hit the over four times.
• The Mariners have a record of 7-3-0 ATS over their last 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh paces the Mariners in home runs (56) and runs batted in (118).
• Raleigh ranks first in homers and third in RBI among all batters in the majors.
• Julio Rodriguez is hitting .269 with 31 doubles, four triples, 31 home runs and 38 walks.
• Among all MLB batters, Rodriguez ranks 14th in homers and 18th in RBI.
• Josh Naylor has accumulated a team-best batting average of .289.
• Eugenio Suarez is batting .228 with 26 doubles, 47 home runs and 44 walks.

Mariners Team Props

Mariners vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Seattle Mariners and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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