Astros vs. Mariners Prediction, Odds, Picks - May 23

Jeremy Pena and the Houston Astros will meet Julio Rodriguez and the Seattle Mariners on Friday at Daikin Park, at 8:10 p.m. ET. Oddsmakers list the Astros as -119 favorites on the moneyline, while giving the underdog Mariners -100 moneyline odds. Houston is the run-line favorite (-1.5). The total is 8.5 runs for the matchup (with -120 odds on the over and -101 odds to go under).

Here's everything you need from a betting perspective on the Astros-Mariners game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Mariners Game Information & Odds

• When: Friday, May 23, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and ROOT Sports NW

Astros vs. Mariners Prediction

• Score Prediction: Astros 5, Mariners 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Astros 54%, Mariners 46%

Astros vs. Mariners Betting Insights

• This season, the Astros have won 18 out of the 33 games, or 54.5%, in which they've been favored.
• Houston has a record of 14-12 in games when sportsbooks favor them by at least -119 on the moneyline.
• The oddsmakers' moneyline implies a 54.3% chance of a victory for the Astros.
• The Mariners have been underdogs in 19 games this season and have come away with the win 11 times (57.9%) in those contests.
• This year, Seattle has won 11 of 18 games when listed as at least -100 or worse on the moneyline.
• The Mariners have an implied victory probability of 50% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros have a 3-1 record over the four games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to hit the over three times.
• The Astros' ATS record is 5-5-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Isaac Paredes is the Astros best power hitter, connecting on 10 homers this season in addition to accumulating 29 RBI, both team highs.
• Of all hitters in baseball, Paredes ranks 22nd in homers and 33rd in RBI.
• Pena has eight doubles, a triple, six home runs and 13 walks while hitting .298.
• Pena ranks 87th in home runs and 67th in RBI on the season.
• Jake Meyers leads the Astros with a team-best batting average of .304.
• Meyers has at least one base hit in seven games in a row. During his last 10 games he is hitting .324 with a double, a home run, three walks and two RBIs.
• Jose Altuve is hitting .243 with six doubles, six home runs and 15 walks.

Astros Team Props

Mariners Recent Betting Performance

• The Mariners have played as underdogs in six of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Mariners and their opponents are 3-7-0 when it comes to hitting the over.
• Over their last 10 games, the Mariners are 6-4-0 against the spread.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh has a team-high 16 home runs and has driven in 33 runs.
• Among all hitters in the majors, Raleigh is third in home runs and 19th in RBI.
• Raleigh carries a three-game hitting streak into this matchup. In his last five games he is batting .250 with two doubles, a home run, two walks and two RBIs.
• Rodriguez is batting .231 with five doubles, two triples, nine home runs and 18 walks.
• Rodriguez ranks 35th in home runs and 42nd in RBI among all MLB hitters this year.
• Jorge Polanco is batting .291 with six doubles, 10 home runs and nine walks.
• J.P. Crawford leads the Mariners with a .262 batting average.

Mariners Team Props

Cal Raleigh smacks 16th homer of the season as Mariners tie game vs. White Sox

Cal Raleigh went yard to help the Seattle Mariners tie game vs. the White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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