Astros vs. Guardians Prediction, Odds, Picks - July 9

Brandon Walter takes the mound for the Houston Astros on Wednesday at Daikin Park against Jose Ramirez and the Cleveland Guardians. First pitch is at 8:10 p.m. ET. Oddsmakers list the Astros as -157 favorites on the moneyline, while giving the underdog Guardians +132 moneyline odds to win. Houston is favored on the run line (-1.5). The total is 7.5 runs for this contest (with -105 odds on the over and -115 odds on the under).

Here is everything you need from a betting perspective on the Astros-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Astros Highlights | MLB on FOX

Check out the best moments between Cleveland Guardians and Houston Astros.

Astros vs. Guardians Game Information & Odds

• When: Wednesday, July 9, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and CLEG

Astros vs. Guardians Prediction

• Score Prediction: Astros 5, Guardians 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 57%, Guardians 43%

Astros vs. Guardians Betting Insights

• This season, the Astros have won 38 out of the 64 games, or 59.4%, in which they've been favored.
• This season Houston has won 11 of its 19 games, or 57.9%, when favored by at least -157 on the moneyline.
• The moneyline for this contest implies a 61.1% chance of a victory for the Astros.
• The Guardians have been victorious in 23, or 40.4%, of the 57 contests they have been chosen as underdogs in this season.
• Cleveland has a mark of 5-13 in contests where oddsmakers favor it by +132 or worse on the moneyline.
• The Guardians have an implied victory probability of 43.1% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros were the moneyline favorite for seven of their last 10 games, and went 3-4 in those matchups.
• Over their last 10 matchups (all had set totals), the Astros combined with their opponents to hit the over on the total six times.
• The Astros' ATS record is 5-5-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Isaac Paredes has homered 19 times this season, the highest mark on the Astros, while hitting .255 with 49 RBI.
• Among all hitters in MLB, Paredes' home run total ranks him 17th, and his RBI tally puts him 50th.
• Jose Altuve has racked up 50 runs batted in to pace his team.
• Altuve is 34th in homers and 43rd in RBI among all batters in MLB.
• Jake Meyers is hitting .308 with 15 doubles, two triples, three home runs and 27 walks.
• Yainer Diaz is batting .242 with 11 doubles, a triple, 12 home runs and 13 walks.

Astros Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in nine of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Guardians and their opponents are 5-5-0 in their last 10 games with a total.
• The Guardians have six wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the squad with a batting average of .299, and paces the Guardians in home runs, with 16 and runs batted in with 44.
• Among all hitters in the majors, Ramirez ranks 34th in home runs and 70th in RBI.
• Steven Kwan has 20 doubles, a triple, six home runs and 30 walks while batting .292.
• Kwan is currently 194th in home runs and 170th in RBI in the big leagues.
• Carlos Santana has seven doubles, 10 home runs and 41 walks while hitting .230.
• Angel Martinez is batting .238 with 13 doubles, a triple, six home runs and nine walks.

Guardians Team Props

Guardians vs. Astros Highlights | MLB on FOX

Check out the best moments between Cleveland Guardians and Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Houston Astros

Cleveland Guardians