Astros vs. Diamondbacks Prediction, Odds, Picks - July 23

Eugenio Suarez and the Arizona Diamondbacks hit the field on Wednesday at Chase Field against Brandon Walter, who will start for the Houston Astros. First pitch is at 3:40 p.m. ET for the final game of a three-game series. The favored Astros have -116 moneyline odds to win against the underdog Diamondbacks, who are listed at -104. Houston is the favorite on the run line (-1.5 with +142 odds). The over/under is 8.5 runs for the game.

Here's everything you need to know from a betting perspective on the Astros-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Diamondbacks Game Information & Odds

• When: Wednesday, July 23, 2025 at 3:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and SCHN

Astros vs. Diamondbacks Prediction

• Score Prediction: Diamondbacks 6, Astros 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Astros 51%, Diamondbacks 49%

Astros vs. Diamondbacks Betting Insights

• This season, the Astros have been favored 69 times and won 40, or 58%, of those games.
• Houston is 36-25 this season when entering a game favored by -116 or more on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 53.7% chance to win.
• The Diamondbacks have been victorious in 17, or 47.2%, of the 36 contests they have been chosen as underdogs in this season.
• Arizona has a mark of 16-16 in contests where sportsbooks favor it by -104 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 51% chance of pulling out a win.

Astros Recent Betting Performance

• The Astros were favored on the moneyline in six of their last 10 games, and they went 2-4 in those matchups.
• In their last 10 outings (all had set totals), the Astros combined with their opponents to hit the over on the total five times.
• The Astros have gone 5-5-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has put up a team-high 53 runs batted in.
• Altuve's home runs rank him 41st in the majors, and he ranks 52nd in RBI.
• Altuve carries a four-game hitting streak into this matchup. During his last five outings he is hitting .333 with three doubles, three walks and an RBI.
• Yainer Diaz has 11 doubles, a triple, 13 home runs and 14 walks while batting .241.
• Of all major league hitters, Diaz is 80th in homers and 118th in RBI.
• Christian Walker has 13 doubles, a triple, 13 home runs and 25 walks while batting .232.
• Walker has at least one base hit in four games in a row. During his last five outings he is hitting .333 with a double, a home run, two walks and four RBIs.
• Cam Smith is hitting .266 with 17 doubles, two triples, seven home runs and 28 walks.

Astros Team Props

Diamondbacks Recent Betting Performance

• The Diamondbacks have played as underdogs in six of their past 10 games and won three of those contests.
• When it comes to hitting the over, the Diamondbacks and their opponents are 5-4-1 in their last 10 games with a total.
• Over their last 10 games, the Diamondbacks are 5-5-0 against the spread.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is batting .275 with 20 doubles, two triples, 10 home runs and 59 walks.
• Among all hitters in MLB, Perdomo ranks 132nd in homers and 10th in RBI.
• Suarez been a consistent power bat this season, as he leads his team with 36 home runs and 86 runs batted in.
• Among all MLB batters, Suarez ranks second in home runs and first in RBI.
• Josh Naylor paces the Diamondbacks with a team-high batting average of .293.
• Corbin Carroll is batting .250 with 17 doubles, 13 triples, 21 home runs and 32 walks.

Diamondbacks Team Props

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Check out the best moments between the Houston Astros and Seattle Mariners.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

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