Astros vs. Cubs Prediction, Odds, Picks - June 29

The Houston Astros and Jeremy Pena will take on the Chicago Cubs and Michael Busch on Sunday at 2:10 p.m. ET, in the final game of a three-game series at Daikin Park. The Astros are the favorite in this one, at -132, while the underdog Cubs have +111 odds to play spoiler. Houston is favored on the run line (-1.5 with +161 odds). The game's over/under is listed at 7.5 runs.

Take a look at everything you need to know from a betting perspective on the Astros-Cubs game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Cubs vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and Houston Astros.

Astros vs. Cubs Game Information & Odds

• When: Sunday, June 29, 2025 at 2:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN

Astros vs. Cubs Prediction

• Score Prediction: Astros 4, Cubs 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Astros 52%, Cubs 48%

Astros vs. Cubs Betting Insights

• The Astros have been favorites in 58 games this season and won 35 (60.3%) of those contests.
• Houston has entered 33 games this season favored by -132 or more and is 23-10 in those contests.
• The oddsmakers' moneyline implies a 56.9% chance of a victory for the Astros.
• The Cubs have been victorious in 10, or 38.5%, of the 26 contests they have been chosen as underdogs in this season.
• This year, Chicago has won three of 10 games when listed as at least +111 or worse on the moneyline.
• The Cubs have an implied victory probability of 47.4% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros have a 6-2 record from the eight games they were moneyline favorites over their last 10 matchups.
• Over their last 10 outings, the Astros and their opponents combined to go over the run total five times (all 10 of the games had set totals).
• The Astros are 3-7-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros best hitter so far this season is Pena, who's hitting at a team-leading .322 clip along with 11 homers and 40 RBI.
• Pena is 68th in home runs and 67th in RBI among all hitters in baseball.
• Isaac Paredes' 17 home runs and 46 runs batted in both pace his team.
• Paredes is 18th in homers and 38th in RBI among all MLB hitters this year.
• Paredes has two straight games with at least one hit. During his last five outings he is hitting .222 with a home run, a walk and an RBI.
• Jose Altuve is hitting .261 with 10 doubles, 12 home runs and 27 walks.
• Jake Meyers has 13 doubles, a triple, three home runs and 24 walks while hitting .307.
• Meyers takes a four-game streak with at least one hit into this one. In his last five games he is hitting .250 with a walk.

Astros Team Props

Cubs Recent Betting Performance

• The Cubs have played as underdogs in three of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Cubs and their opponents are 8-2-0 when it comes to hitting the over.
• Over their last 10 games, the Cubs are 4-6-0 against the spread.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is hitting .291 with 17 doubles, four triples, 17 home runs and 53 walks.
• Tucker's home run total places him 18th in the big leagues, and he ranks 22nd in RBI.
• Pete Crow-Armstrong is hitting .266 with 20 doubles, three triples, 21 home runs and 15 walks.
• Crow-Armstrong is eighth in homers and eighth in RBI among all major league hitters this year.
• Seiya Suzuki leads the Cubs in home runs (22) and runs batted in (69).
• Nico Hoerner paces the Cubs with a team-high batting average of .294.

Cubs Team Props

Cubs vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Chicago Cubs and Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Houston Astros

Chicago Cubs