Astros vs. Athletics Prediction, Odds, Picks - September 24

Luis Severino will start for the Athletics against Jeremy Pena and the Houston Astros on Wednesday at 10:05 p.m. ET. Oddsmakers list the Astros as -136 favorites on the moneyline, while giving the underdog Athletics +115 moneyline odds. The Astros are favored on the run line (-1.5). The total for the matchup has been listed at 9 runs.

Check out everything you need to know from a betting perspective on the Astros-Athletics game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Mariners vs. Astros Highlights | MLB on FOX

Check out the best highlights between the Seattle Mariners and the Houston Astros.

Astros vs. Athletics Game Information & Odds

• When: Wednesday, September 24, 2025 at 10:05 p.m. ET
• Where: Sutter Health Park in West Sacramento, California
• How to watch on TV: NBCS-CA and SCHN

Astros vs. Athletics Prediction

• Score Prediction: Athletics 6, Astros 5
• Total Prediction: Over 9 runs
• Win Probabilities: Astros 52%, Athletics 48%

Astros vs. Athletics Betting Insights

• The Astros have won 52, or 52%, of the 100 games they've played as favorites this season.
• The Astros have a record of 29-22, a 56.9% win rate, when they're favored by -136 or more by sportsbooks this season.
• The sportsbooks' moneyline implies a 57.6% chance of a victory for the Astros.
• The Athletics have been victorious in 55, or 47%, of the 117 contests they have been chosen as underdogs in this season.
• This year, the Athletics have won 30 of 76 games when listed as at least +115 or better on the moneyline.
• The Athletics have an implied victory probability of 46.5% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros played as the moneyline favorite in five of their last 10 games, and they finished 2-3 in those matchups.
• In their last 10 outings, the Astros and their opponents combined to hit the over six times (all 10 of the games had set totals).
• The Astros' ATS record is 5-5-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has a team-high 26 home runs.
• Altuve is 39th in homers and 64th in RBI among all hitters in the majors.
• Jeremy Pena is hitting .304 to pace his team.
• Pena ranks 110th in homers and 108th in RBI among all hitters in baseball.
• Yainer Diaz is batting .256 with 23 doubles, a triple, 19 home runs and 20 walks.
• Carlos Correa is batting .272 with 27 doubles, 13 home runs and 43 walks.

Astros Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in six of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Athletics and their opponents have combined to hit the over three times.
• The Athletics have won seven of their last 10 games against the spread.

Athletics Recent Stats

Athletics Player Insights

• Brent Rooker is batting .264 with 40 doubles, three triples, 30 home runs and 62 walks, while getting on base at a rate of .335.
• Among all hitters in the majors, Rooker ranks 21st in homers and 31st in RBI.
• Tyler Soderstrom has been productive as he leads his team with 91 runs batted in.
• Soderstrom is 51st overall in homers and 25th in RBI this year.
• Jacob Wilson paces the Athletics with a team-high batting average of .318.
• Nick Kurtz leads the Athletics with 33 home runs.

Athletics Team Props

Athletics vs. Pirates Highlights | MLB on FOX

Check out the best highlights between the Athletics and the Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Athletics

Houston Astros