Astros vs. Athletics Prediction, Odds, Picks - May 28

Lawrence Butler and the Athletics take the field on Wednesday at Daikin Park against Lance McCullers, who is projected to start for the Houston Astros. First pitch is at 2:10 p.m. ET for the final game of a two-game series. The Astros are favored in this one, at -239, while the underdog Athletics have +196 odds to play spoiler. The Astros are favored on the run line (-1.5). The over/under is 8 runs for the contest.

Here's everything you need to know from a betting perspective on the Astros-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Athletics Game Information & Odds

• When: Wednesday, May 28, 2025 at 2:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and NBCS-CA

Astros vs. Athletics Prediction

• Score Prediction: Astros 6, Athletics 4
• Total Prediction: Over 8 runs
• Win Probabilities: Astros 58%, Athletics 42%

Astros vs. Athletics Betting Insights

• The Astros have won 19, or 54.3%, of the 35 games they've played as favorites this season.
• The Astros have played as a favorite of -239 or more once this season and won that game.
• The bookmakers' moneyline implies a 70.5% chance of a victory for the Astros.
• The Athletics have won in 14, or 37.8%, of the 37 contests they have been named as odds-on underdogs this year.
• The Athletics have been listed as an underdog of +196 or more on two occasions this season and lost both games.
• The Athletics have an implied victory probability of 33.8% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros went 2-2 over the four games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Astros and their opponents combined to hit the over three times (all 10 of the games had set totals).
• The Astros' ATS record is 6-4-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros' best power option comes in the form of Isaac Paredes and his 11-homer 31-RBI season, both team highs.
• Of all hitters in the majors, Paredes' home run total ranks him 21st, and his RBI tally puts him 31st.
• Jeremy Pena is hitting .298 with eight doubles, a triple, seven home runs and 14 walks.
• Of all MLB hitters, Pena ranks 78th in home runs and 66th in RBI.
• Pena has three straight games with at least one hit. During his last five outings he is batting .300 with a triple, a home run, a walk and four RBIs.
• Jose Altuve is batting .272 with six doubles, eight home runs and 16 walks.
• Altuve will look to build on his five-game hitting in this matchup. In his last five games he is batting .571 with four home runs, a walk and seven RBIs.
• Jake Meyers' .299 batting average leads his team.

Astros Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in six of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Athletics and their opponents have combined to hit the over five times.
• The Athletics have won four of their last 10 games against the spread.

Athletics Recent Stats

Athletics Player Insights

• Jacob Wilson paces the Athletics with a team-high batting average of .348.
• In all of the big leagues, Wilson ranks 99th in homers and 58th in RBI.
• Wilson has collected a hit in three straight games. In his last five games he is batting .409 with a double, a home run, two walks and two RBIs.
• Brent Rooker has shown off his power as he leads his team with 12 home runs.
• Rooker is currently 14th in homers and 75th in RBI in the major leagues.
• Tyler Soderstrom has sent home a team-high 31 runs batted in.
• Butler is hitting .252 with 15 doubles, a triple, eight home runs and 17 walks.

Athletics Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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